Recombinant Full Length Human TP63 Protein, C-Flag-tagged

• Cat.No.: TP63-1244HFL
• Product Overview: Recombinant Full Length Human TP63 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 76.6 kDa
• AA Sequence: MNFETSRCATLQYCPDPYIQRFVET PAHFSWKESYYRSTMSQSTQTNEFL SPEVFQHIWDFLEQPICSVQ PIDLNFVDEPSEDGATNKIEISMDC IRMQDSDLSDPMWPQYTNLGLLNSM DQQIQNGSSSTSPYNTDHAQ NSVTAPSPYAQPSSTFDALSPSPAI PSNTDYPGPHSFDVSFQQSSTAKSA TWTYSTELKKLYCQIAKTCP IQIKVMTPPPQGAVIRAMPVYKKAE HVTEVVKRCPNHELSREFNEGQIAP PSHLIRVEGNSHAQYVEDPI TGRQSVLVPYEPPQVGTEFTTVLYN FMCNSSCVGGMNRRPILIIVTLETR DGQVLGRRCFEARICACPGR DRKADEDSIRKQQVSDSTKNGDGTK RPFRQNTHGIQMTSIKKRRSPDDEL LYLPVRGRETYEMLLKIKES LELMQYLPQHTIETYRQQQQQQHQH LLQKQTSIQSPSSYGNSSPPLNKMN SMNKLPSVSQLINPQQRNAL TPTTIPDGMGANIPMMGTHMPMAGD MNGLSPTQALPPPLSMPSTSHCTPP PPYPTDCSIVSFLARLGCSS CLDYFTTQGLTTIYQIEHYSMDDLA SLKIPEQFRHAIWKGILDHRQLHEF SSPSHLLRTPSSASTVSVGS
  SETRGERVIDAVRFTLRQTISFPPR DEWNDFNFDMDARRNKQQRIKEEGE TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors

Gene Information

• Gene Name: TP63 tumor protein p63 [ Homo sapiens (human) ]
• Official Symbol: TP63
• Synonyms: AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B)
• Gene ID: 8626
• mRNA Refseq: NM_003722.5
• Protein Refseq: NP_003713.3
• MIM: 603273
• UniProt ID: Q9H3D4