Recombinant Full Length Human TTR Protein, C-Flag-tagged

• Cat.No.: TTR-1220HFL
• Product Overview: Recombinant Full Length Human TTR Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 13.7 kDa
• AA Sequence: MASHRLLLLCLAGLVFVSEAGPTGT GESKCPLMVKVLDAVRGSPAINVAV HVFRKAADDTWEPFASGKTS ESGELHGLTTEEEFVEGIYKVEIDT KSYWKALGISPFHEHAEVVFTANDS GPRRYTIAALLSPYSYSTTA
  VVTNPKETRTRPLEQKLISEEDLAA NDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: ES Cell Differentiation/IPS, Secreted Protein

Gene Information

• Gene Name: TTR transthyretin [ Homo sapiens (human) ]
• Official Symbol: TTR
• Synonyms: CTS; TTN; ATTR; CTS1; PALB; TBPA; HEL111; HsT2651
• Gene ID: 7276
• mRNA Refseq: NM_000371.4
• Protein Refseq: NP_000362.1
• MIM: 176300
• UniProt ID: P02766