Recombinant Full Length Human TYROBP Protein, C-Flag-tagged
Cat.No. : | TYROBP-1569HFL |
Product Overview : | Recombinant Full Length Human TYROBP Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 9.3 kDa |
AA Sequence : | MGGLEPCSRLLLLPLLLAVSGLRPV QAQAQSDCSCSTVSPGVLAGIVMGD LVLTVLIALAVYFLGRLVPRGRGAA EAATRKQRITETESPYQELQGQRSD VYSDLNTQRPYYK TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Transmembrane |
Protein Pathways : | Natural killer cell mediated cytotoxicity |
Gene Name : | TYROBP transmembrane immune signaling adaptor TYROBP [ Homo sapiens (human) ] |
Official Symbol : | TYROBP |
Synonyms : | DAP12; KARAP; PLOSL; PLOSL1 |
Gene ID : | 7305 |
mRNA Refseq : | NM_003332.4 |
Protein Refseq : | NP_003323.1 |
MIM : | 604142 |
UniProt ID : | O43914 |
Products Types
◆ Recombinant Protein | ||
TYROBP-4857R | Recombinant Rhesus Macaque TYROBP Protein, His (Fc)-Avi-tagged | +Inquiry |
TYROBP-6039R | Recombinant Rat TYROBP Protein, His (Fc)-Avi-tagged | +Inquiry |
TYROBP-519H | Recombinant Human TYROBP Protein, His&GST-tagged | +Inquiry |
TYROBP-9801M | Recombinant Mouse TYROBP Protein, His (Fc)-Avi-tagged | +Inquiry |
Tyrobp-6759M | Recombinant Mouse Tyrobp Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
TYROBP-613HCL | Recombinant Human TYROBP 293 Cell Lysate | +Inquiry |
TYROBP-614HCL | Recombinant Human TYROBP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket