Recombinant Full Length Human XRN2 Protein, C-Flag-tagged

• Cat.No.: XRN2-465HFL
• Product Overview: Recombinant Full Length Human XRN2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 108.4 kDa
• AA Sequence: MGVPAFFRWLSRKYPSIIVNCVEEK PKECNGVKIPVDASKPNPNDVEFDN LYLDMNGIIHPCTHPEDKPA PKNEDEMMVAIFEYIDRLFSIVRPR RLLYMAIDGVAPRAKMNQQRSRRFR ASKEGMEAAVEKQRVREEIL AKGGFLPPEEIKERFDSNCITPGTE FMDNLAKCLRYYIADRLNNDPGWKN LTVILSDASAPGEGEHKIMD YIRRQRAQPNHDPNTHHCLCGADAD LIMLGLATHEPNFTIIREEFKPNKP KPCGLCNQFGHEVKDCEGLP REKKGKHDELADSLPCAEGEFIFLR LNVLREYLERELTMASLPFTFDVER SIDDWVFMCFFVGNDFLPHL PSLEIRENAIDRLVNIYKNVVHKTG GYLTESGYVNLQRVQMIMLAVGEVE DSIFKKRKDDEDSFRRRQKE KRKRMKRDQPAFTPSGILTPHALGS RNSPGSQVASNPRQAAYEMRMQNNS SPSISPNTSFTSDGSPSPLG GIKRKAEDSDSEPEPEDNVRLWEAG WKQRYYKNKFDVDAADEKFRRKVVQ SYVEGLCWVLRYYYQGCASW KWYYPFHYAPFASDFEGIADMPSDF EKGTKPFKPLEQLMGVFPAASGNFL PPSWRKLMSDPDSSIIDFYP EDFAIDLNGKKYAWQGVALLPFVDE RRLRAALEEVYPDLTPEETRRNSLG GDVLFVGKHHPLHDFILELY QTGSTEPVEVPPELCHGIQGKFSLD EEAILPDQIVCSPVPMLRDLTQNTV VSINFKDPQFAEDYIFKAVM LPGARKPAAVLKPSDWEKSSNGRQW KPQLGFNRDRRPVHLDQAAFRTLGH VMPRGSGTGIYSNAAPPPVT YQGNLYRPLLRGQAQIPKLMSNMRP QDSWRGPPPLFQQQRFDRGVGAEPL LPWNRMLQTQNAAFQPNQYQ
  MLAGPGGYPPRRDDRGGRQGYPREG RKYPLPPPSGRYNWNTRTRPLEQKL ISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Pathways: RNA degradation

Gene Information

• Gene Name: XRN2 5'-3' exoribonuclease 2 [ Homo sapiens (human) ]
• Official Symbol: XRN2
• Synonyms: 5'-3' exoribonuclease 2; Dhm1-like protein (mouse homolog); OTTHUMP00000030403
• Gene ID: 22803
• mRNA Refseq: NM_012255.5
• Protein Refseq: NP_036387.2
• MIM: 608851
• UniProt ID: Q9H0D6