Recombinant Full Length Mouse Adenosine Receptor A3(Adora3) Protein, His-Tagged

• Cat.No.: RFL32181MF
• Product Overview: Recombinant Full Length Mouse Adenosine receptor A3(Adora3) Protein (Q61618) (1-319aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Mus musculus (Mouse)
• Tag: His
• Form: Lyophilized powder
• Protein Length: Full Length (1-319)
• AA Sequence: MEADNTTETDWLNITYITMEAAIGL CAVVGNMLVIWVVKLNPTLRTTTVY FIVSLALADI AVGVLVIPLAIAVSLQVKMHFYACL FMSCVLLIFTHASIMSLLAIAVHRY LRVKLTVRYR TVTTQRRIWLFLGLCWLVSFLVGLT PMFGWNRKATLASSQNSSTLLCHFR SVVSLDYMVF FSFITWILVPLVVMCIIYLDIFYII RNKLSQNLTGFRETRAFYGREFKTA KSLFLVLFLF ALCWLPLSIINFVSYFDVKIPDVAM CLGILLSHANSMMNPIVYACKIKKF KETYFLILRA VRLCQTSDSLDSNMEQTTE
• Purity: Greater than 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: Adora3
• Synonyms: Adora3; Gpcr2; Adenosine receptor A3; A3AR
• UniProt ID: Q61618

Gene Information

• Gene Name: Adora3
• Synonyms: Adora3; Gpcr2; Adenosine receptor A3; A3AR
• UniProt ID: Q61618

Reviews

06/01/2021

Its excellent solubility and stability properties have given me confidence in its reliability.

10/17/2018

The purity and consistency of this protein have surpassed my expectations, making it an ideal choice for my research.

06/18/2018

the technical team has been extremely responsive and knowledgeable, offering valuable insights and solutions to any concerns I had.

Q&As

Are there any drugs currently on the market that target ADORA3 proteins?

There are currently no drugs available that specifically target ADORA3 proteins. However, there are drugs that target other adenosine receptors, such as caffeine (which blocks adenosine receptors), methylxanthines (which block both adenosine A1 and A2A receptors), and antiarrhythmic drugs (which target adenosine A1 receptors in the heart).

What are ADORA3 proteins?

ADORA3 proteins, also known as adenosine A3 receptors, are a subtype of adenosine receptors that are found in various tissues throughout the body including the brain, heart, lungs, liver, and immune cells. These receptors are responsible for mediating the effects of adenosine, a signaling molecule that regulates various physiological processes including inflammation, immune function, and cardiovascular function.

What are some challenges associated with developing drugs that target ADORA3 proteins?

One challenge is the potential for side effects, as these receptors are found in multiple tissues throughout the body and have diverse effects on various physiological processes. Therefore, drugs targeting ADORA3 proteins may have off-target effects on other tissues and systems. Additionally, ADORA3-targeting drugs may need to be developed with specific dosing strategies or combinations with other medications to be effective against certain diseases.