Recombinant Full Length Rat Type-1 Angiotensin Ii Receptor-Associated Protein(Agtrap) Protein, His-Tagged
Cat.No. : | RFL28862RF |
Product Overview : | Recombinant Full Length Rat Type-1 angiotensin II receptor-associated protein(Agtrap) Protein (Q642A2) (1-160aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Rattus norvegicus (Rat) |
Tag : | His |
Form : | Lyophilized powder |
Protein Length : | Full Length (1-160) |
AA Sequence : | MELPAVNLKVILLVHWLLTTWGCLA FSGSYAWGNFTILALGVWAVAQRDS VDAIGMFLGG LVATIFLDIIYISIFYSSVAVGDTG RFSAGMAIFSLLLKPFSCCLVYHMH RERGGELPLR SDFFGPSQEHSAYQTIDSSDSPADP LASLENKGQAAPRGY |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | Agtrap |
Synonyms : | Agtrap; Atrap; Type-1 angiotensin II receptor-associated protein; AT1 receptor-associated protein |
UniProt ID : | Q642A2 |
Gene Name : | Agtrap |
Synonyms : | Agtrap; Atrap; Type-1 angiotensin II receptor-associated protein; AT1 receptor-associated protein |
UniProt ID : | Q642A2 |
Products Types
◆ Recombinant Protein | ||
AGTRAP-102R | Recombinant Rhesus Macaque AGTRAP Protein, His (Fc)-Avi-tagged | +Inquiry |
Agtrap-98M | Recombinant Mouse Agtrap Protein, His&GST-tagged | +Inquiry |
AGTRAP-224R | Recombinant Rat AGTRAP Protein, His (Fc)-Avi-tagged | +Inquiry |
AGTRAP-399M | Recombinant Mouse AGTRAP Protein, His (Fc)-Avi-tagged | +Inquiry |
AGTRAP-9486H | Recombinant Human AGTRAP, GST-tagged | +Inquiry |
◆ Lysates | ||
AGTRAP-8968HCL | Recombinant Human AGTRAP 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionYes, dysregulation of AGTRAP expression or function has been implicated in various cardiovascular conditions, including hypertension, cardiac hypertrophy, and heart failure.
Yes, AGTRAP can regulate AGTR1 expression by influencing its trafficking and degradation, thus impacting the overall abundance of AGTR1 receptors.
AGTRAP can modulate AGTR1 signaling by affecting the receptor's coupling to downstream signaling pathways, including G proteins and β-arrestins.
AGTRAP is widely expressed in various tissues, including the heart, kidney, liver, and brain.
AGTRAP acts as a negative regulator of AGTR1, thereby modulating the effects of angiotensin II on blood pressure control and vascular function.
AGTRAP is primarily localized in the endoplasmic reticulum (ER) and Golgi apparatus, where it interacts with AGTR1 during receptor maturation and trafficking.
AGTRAP physically associates with AGTR1 and modulates its activity by influencing receptor trafficking, signaling, and desensitization.
While the precise involvement of AGTRAP in specific diseases is still being elucidated, dysregulation of AGTRAP has been associated with cardiovascular diseases, hypertension, and altered response to angiotensin II.
AGTRAP has been reported to interact with several proteins involved in receptor trafficking, including G protein-coupled receptor-associated sorting proteins (GASP), which influence AGTR1 cell surface expression.
Techniques such as immunoprecipitation, co-immunoprecipitation, fluorescence microscopy, and genetic manipulation in cellular and animal models are employed to investigate AGTRAP's role and molecular mechanisms.
Customer Reviews (5)
Write a reviewIt was delivered quickly, and the product was of exceptional quality, meeting all my research needs.
Outstanding products. Impressive results!
The protein I purchased was a game-changer for my experiments. Its high activity and purity significantly improved the reliability of my findings
Reliable and high-quality protein. Recommended!
I've been using proteins for years, and this one ranks among the best.
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