Recombinant Full Length Xenopus Tropicalis Monoacylglycerol Lipase Abhd12(Abhd12) Protein, His-Tagged
Cat.No. : | RFL-17285XF |
Product Overview : | Recombinant Full Length Xenopus tropicalis Monoacylglycerol lipase ABHD12(abhd12) Protein (B4F753) (1-386aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Tag : | His |
Form : | Lyophilized powder |
Protein length : | Full Length (1-386) |
AA Sequence : | MRKRAEPVPPEHESFGRAPLDRECS IKQKLRIPGTKGHYPHDSDCDSKGM KRFGRRYGLWSRLRMFLIFLLGLYI AIPFLVKICPAIQTQLVFLNLVRFP YFIDLKRPEDQGLNHTCNFYLQPEE DVSIGVWHTVPAVLWKDAQGKDLEW YEEVLSTSYPVILYLHGNAGTRGGD HRVQLYKVLSSMGYHVISFDYRGWG DSVGSPSESGMTYDALHVFDWIKAR SGDNPVYIWGHSLGTGVATNLVRRL CERETPPDSLILESPFTNIREEAKS HPFSVIYRYFPGFDWFFLDPITASG IKFANDDNVKYISCPLLILHAEDDP VIPFHLGKKLYNIAAPARSLRDYKV QFVPFHKDLGYRHKYIYRSPELRQI LRDFLGNTEQQ |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Applications : | SDS-PAGE |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | abhd12 |
Synonyms : | abhd12; Lysophosphatidylserine lipase ABHD12; 2-arachidonoylglycerol hydrolase ABHD12; Abhydrolase domain-containing protein 12; Monoacylglycerol lipase ABHD12; Oxidized phosphatidylserine lipase ABHD12 |
UniProt ID : | B4F753 |
Gene Name : | abhd12 |
Synonyms : | abhd12; Lysophosphatidylserine lipase ABHD12; 2-arachidonoylglycerol hydrolase ABHD12; Abhydrolase domain-containing protein 12; Monoacylglycerol lipase ABHD12; Oxidized phosphatidylserine lipase ABHD12 |
UniProt ID : | B4F753 |
Products Types
◆ Recombinant Protein | ||
ABHD12-212M | Recombinant Mouse ABHD12 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABHD12-73R | Recombinant Rat ABHD12 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABHD12-15R | Recombinant Rhesus Macaque ABHD12 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABHD12-247H | Recombinant Human ABHD12 Protein, His (Fc)-Avi-tagged | +Inquiry |
Abhd12-1467M | Recombinant Mouse Abhd12 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
ABHD12-9HCL | Recombinant Human ABHD12 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionThis gene is overexpressed in nasal epithelium and bone.
Lipase inhibitor for obesity treatment, Small Molecule, Anti-Obesity Agents, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity
Phospholipid catabolic process, Lipid metabolic process, and Protein depalmitoylation.
They are DPP9, HSCB, COASY, SLC39A4, and SRSF1.
Arachidonate production from DAG, Effects of PIP2 hydrolysis, and GPCR downstream signalling.
It can be determined by analysing ABHD12 mRNA expression in breast cancer tissues and healthy tissues, based on a series of research, we found that mRNA expression profile revealed that the ABHD12 transcript is highly expressed in tissues of patients with breast cancer compared to that expressed in healthy tissues adjacent to tumour.
Disruption of ABHD12 in mice leads to (i) accumulation of lyso-PS in the cerebellum breaching the homeostatic threshold, inducing continuous stimulation of the Purkinje neurons, leading to deregulated cerebellar activity and (ii) increased levels of microglial activation and inflammation. Accompanying this inflammatory response in mice are behavioral deficits, including sensorimotor defects and hearing loss.
Lysophosphatidylserine (i.e. ABHD12) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes, represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system.
Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract)
It is because this gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation
Customer Reviews (3)
Write a reviewThe product description covers all product attributes and application methods, and will repurchase.
The packaging is intact with clear labels, cool.
Reasonable price!
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