Recombinant Human ABCB11 Protein, His6ABP-tagged

• Cat.No.: ABCB11-01H
• Product Overview: Recombinant protein fragment of Human ABCB11 with N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G) fusion tag was expressed in E. coli.

Specification

• Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.
• Source: E. coli
• Species: Human
• Tag: His6ABP
• Form: Buffered aqueous solution
• Molecular Mass: 33 kDa
• AA Sequence: RLSTVRAADTIIGFEHGTAVERGTH EELLERKGVYFTLVTLQSQGNQALN EEDIKDATEDDMLARTFSRGSYQDS LRASIRQRSKSQLSYLVHEPPLAVV DHKSTYEEDRKDKDIPVQEEVEPAP VRRILK
• Purity: > 80% by SDS-PAGE
• Applications: Suitable as a blocking agent using corresponding antibodies.
• Usage: The protein solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.
• Storage: At −20 centigrade.
• Concentration: ≥0.5 mg/mL
• Storage Buffer: Solution in 1 M urea-PBS, pH 7.4
• Shipping: Wet ice.

Gene Information

• Gene Name: ABCB11 ATP binding cassette subfamily B member 11 [ Homo sapiens (human) ]
• Official Symbol: ABCB11
• Synonyms: ABCB11; ATP binding cassette subfamily B member 11; BSEP; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2; bile salt export pump; ABC member 16, MDR/TAP subfamily; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; progressive familial intrahepatic cholestasis 2; sister p-glycoprotein
• Gene ID: 8647
• mRNA Refseq: NM_003742
• Protein Refseq: NP_003733
• MIM: 603201
• UniProt ID: O95342