Recombinant Human ABCC13 Protein, GST-Tagged

• Cat.No.: ABCC13-046H
• Product Overview: Human ABCC13 full-length ORF ( ENSP00000345983, 1 a.a. - 169 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 45.9 kDa
• AA Sequence: MLSSTQNAGGSYQRVRGALDTQKCS PEKSASFFSKVTYSWFSRVITLGYK RPLEREDLFELKESDSFCTACPIFE KQWRKEVLRNQERQKVKVSCYKEAH IKKPSLLYALWNTFKSILIQVALFK VFADILSFTSPLIMNYTRKVNYLMG LPCENQKITSYSQASGRDS
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene [ Homo sapiens ]
• Official Symbol: ABCC13
• Synonyms: ABCC13; ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene; ATP binding cassette, sub family C (CFTR/MRP), member 13; ATP-binding cassette protein C13; C21orf73; PRED6
• Gene ID: 150000
• mRNA Refseq: NM_138726
• MIM: 608835
• UniProt ID: Q9NSE7

Reviews

08/07/2019

The strip is clear and of high quality

03/09/2018

Proper purity

08/05/2017

Fast transportation

Q&As

How long does it take for the product to be shipped?

It depends on your location, we usually use FedEx to send our products.

Which proteins does ABCC13 interact with in Globin Switching

Including hist1h2bl, al133243.2, trim58, abcc13, bpgm, and fam210b were identified in the coexpression network

How ABCC13 works with immune cells?

Except for ABCC12/13, the ABCCs were significantly associated with B cell, CD8+ T cell, CD4+ T cell, macrophage, neutrophil, and dendritic cell infiltration

what's the stucture of ABCC13

The ABCC13 gene spans approximately 70kb on human chromosome 21q11.2 and consists of 14 exons. The open reading frame of the ABCC13 cDNA encodes a peptide consisting of 325 amino acid residues. The amino acid sequence corresponding to putative membrane-spanning domains was remarkably similar to ABCC1, ABCC2, ABCC3, and ABCC6.

Could ABCC13 be the biomarker for lung adenocarcinoma?

While some studies have investigated the potential of ABCC13 as a biomarker for lung adenocarcinoma, further research is needed to determine its clinical utility and to confirm its specificity and sensitivity as a diagnostic and prognostic marker for this type of cancer.

Where does ABCC13 express more in the human body

The ABCC13 gene was expressed in the fetal liver at the highest level among the organs studied. While ABCC13 was expressed in the bone marrow, its expression in peripheral blood leukocytes of adult humans was much lower and no detectable levels were observed in differentiated hematopoietic cells.

Why does ABCC13 belong to MRP class?

ABCC13 shares a similar structure to other MRP transporters, with three TMDs and two NBDs. Although its function is not yet fully characterized, studies suggest that it may be involved in the transport of glutathione and other conjugates.

Does ABCC13 have multidrug resistance function?

MRP10/ABCC13 is clearly a pseudo-gene which encodes a truncated protein that is highly expressed in fetal human liver with the highest similarity to MRP2/ABCC2 but without transporting activity.

Is ABCC13 related to colon cancer?

There is no clear evidence at present that ABCC13 is directly linked to colon cancer.

Where is ABCC13 located on the chromosome

21q11.2-q21.1

What's the role of ABCC13 in wheat?

Study data demonstrate that wheat ABCC13 is functionally important for grain development and plays an important role during detoxification of heavy metals.