Recombinant Human ACADVL, His-tagged
Cat.No. : | ACADVL-785H |
Product Overview : | Recombinant humanACADVL protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 68.5 kDa (636aa). |
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Cat. No. : | ACADVL-785H |
Description : | ACADVL, also known as VLCAD, LCACD or ACAD6, is an inner mitochondrial membrane protein that belongs to the family of acyl-CoA dehydrogenases. This protein is involved in lipid metabolism and has catalytic activity toward esters of long chain and very long chain fatty acids such as palmitoyl-CoA and stearoyl-CoA, and functions in the first step of the fatty acid β-oxidation pathway. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. |
Source : | E.coli. |
Sequences Of Amino Acids : | MGSSHHHHHH SSGLVPRGSH MAGGAAQLAL DKSDSHPSDA LTRKKPAKAE SKSFAVGMFK GQLTTDQVFP YPSVLNEEQT QFLKELVEPV SRFFEEVNDP AKNDALEMVE ETTWQGLKEL GAFGLQVPSE LGGVGLCNTQ YARLVEIVGM HDLGVGITLG AHQSIGFKGI LLFGTKAQKE KYLPKLASGE TVAAFCLTEP SSGSDAASIR TSAVPSPCGK YYTLNGSKLW ISNGGLADIF TVFAKTPVTD PATGAVKEKI TAFVVERGFG GITHGPPEKK MGIKASNTAE VFFDGVRVPS ENVLGEVGSG FKVAMHILNN GRFGMAAALA GTMRGIIAKA VDHATNRTQF GEKIHNFGLI QEKLARMVML QYVTESMAYM VSANMDQGAT DFQIEAAISK IFGSEAAWKV TDECIQIMGG MGFMKEPGVE RVLRDLRIFR IFEGTNDILR LFVALQGCMD KGKELSGLGS ALKNPFGNAG LLLGEAGKQL RRRAGLGSGL SLSGLVHPEL SRSGELAVRA LEQFATVVEA KLIKHKKGIV NEQFLLQRLA DGAIDLYAMV VVLSRASRSL SEGHPTAQHE KMLCDTWCIE AAARIREGMA ALQSDPWQQE LYRNFKSISK ALVERGGVVT SNPLGF |
Purity : | > 95% by SDS – PAGE. |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 1mM DTT, 1mM EDTA, 0.1M NaCl. |
Concentration : | 0.5 mg/ml (determined by Bradford assay). |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | ACADVL acyl-CoA dehydrogenase, very long chain [ Homo sapiens ] |
Synonyms : | ACADVL; acyl-CoA dehydrogenase, very long chain; ACAD6; LCACD; VLCAD; very long-chain specific acyl-CoA dehydrogenase, mitochondrial; EC 1.3.99.-; acyl-Coenzyme A dehydrogenase, very long chain |
Gene ID : | 37 |
mRNA Refseq : | NM_000018 |
Protein Refseq : | NP_000009 |
MIM : | 609575 |
UniProt ID : | P49748 |
Chromosome Location : | 17p13.1 |
Pathway : | Fatty acid metabolism; Metabolic pathways |
Function : | FAD binding; long-chain-acyl-CoA dehydrogenase activity |
Products Types
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ACADVL-95R | Recombinant Rat ACADVL Protein, His (Fc)-Avi-tagged | +Inquiry |
ACADVL-11890Z | Recombinant Zebrafish ACADVL | +Inquiry |
◆ Lysates | ||
ACADVL-9111HCL | Recombinant Human ACADVL 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionThe recombinant ACADVL protein can be used in various applications, such as enzyme assays, drug screening, and protein-protein interaction studies.
The recommended usage guidelines can vary depending on the specific application, but typically involve optimizing the protein concentration, buffer conditions, and other experimental parameters.
Sure, ACADVL has been suggested as a potential biomarker for various diseases, including non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
ACADVL deficiency reduces myocardial fatty acid β-oxidation and is associated with cardiomyopathy. In addition, very long-chain acyl-CoA dehydrogenase deficiency is a rare, life-threatening disorder of mitochondrial fatty acid oxidation metabolism caused by mutations in the ACADVL gene.
Mutations in the ACADVL gene can lead to VLCADD, a rare inherited disorder that affects the metabolism of VLCFAs. Symptoms of VLCADD can include muscle weakness, lethargy, and hypoglycemia. A recent study investigated the impact of ACADVL deficiency on mitochondrial function and found that it leads to impaired fatty acid oxidation and increased oxidative stress.
These quality control measures can include testing for purity, concentration, and functionality, as well as ensuring the protein is free from contaminants, such as endotoxins or microbial contaminants.
Sure, you can describe the specific mutation site in the online form, and our scientists will tailor the corresponding protein products for you.
ACADVL has been implicated in several lipid metabolic pathways, including the beta-oxidation of fatty acids, the biosynthesis of unsaturated fatty acids, and the synthesis of ether lipids.
You can submit specific requirements, and our experts will contact you.
Our high-purity recombinant proteins are suitable for biophysics-related research, such as structural elucidation, molecular dynamics simulations, and interaction studies.
Customer Reviews (3)
Write a reviewI was very impressed with the customized recombinant protein that Creative BioMart created for me. The technical support experts were extremely helpful and accommodating, and the product exceeded my expectations.
I have been consistently impressed with the quality and purity of Creative BioMart's recombinant ACADVL proteins. Their products are reliable and cost-effective, and I plan to repurchase from them in the future.
Thanks to Creative BioMart's ACADVL recombinant protein, I was able to save a significant amount of time on my project. The product was of high quality and reasonably priced.
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