Recombinant Human ACP1, GST-tagged

• Cat.No.: ACP1-9306H
• Product Overview: Recombinant Human ACP1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 15-102a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ACP1 acid phosphatase 1, soluble [ Homo sapiens ]
• Official Symbol: ACP1
• Synonyms: ACP1; acid phosphatase 1, soluble; low molecular weight phosphotyrosine protein phosphatase; LMW-PTP; LMW-PTPase; adipocyte acid phosphatase; red cell acid phosphatase 1; protein tyrosine phosphatase; acid phosphatase of erythrocyte; cytoplasmic phosphotyrosyl protein phosphatase; low molecular weight cytosolic acid phosphatase; HAAP; MGC3499; MGC111030
• Gene ID: 52
• mRNA Refseq: NM_001040649
• Protein Refseq: NP_001035739
• MIM: 171500
• UniProt ID: P24666
• Chromosome Location: 2p25
• Pathway: Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; EPHA2 forward signaling, organism-specific biosystem; PDGFR-beta signaling pathway, organism-specific biosystem; Riboflavin metabolism, organism-specific biosystem; Riboflavin metabolism, conserved biosystem; T Cell Receptor Signaling Pathway, organism-specific biosystem
• Function: acid phosphatase activity; hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity; protein binding

Reviews

02/17/2023

The answers are very concise.

02/16/2023

There are all the questions I want to know.

02/16/2023

The answer was very patient.

Q&As

What are the two subtypes of ACP1?

F and S.

How to analyze ACP1 polymorphism?

Through the polymerase chain reaction-resreiction fragment length polymorphism.

What disease would be influenced by ABHD14A?

Esophageal cancer, gastric cancer and gastrointestinal cancer will lead to up-regulation of ACP1 expression, while colorectal cancer will reduce it.

Why is the blood glucose level of inactive ACP1 A low?

Because ACP1 has low dephosphorylation effect on insulin receptor.

How ACP1 works on respiration and cell oxidation?

To adjust the level of FMN and flavin adenine dinucleotide.

How to detect the protein level of ACP1?

Immunohistochemical staining observation of two related protein sections.

How many codominant alleles are there in ACP1?

Three.

What activities may ACP1 participate in the brain?

The cholesterol biosynthesis, neutotransmitter synthesis and it links to behavioral and cellular response to stress via p190RhoGAP

What's the ACP1 blocking buffer？

The PBS conraining 10% goat serum.

What protein is significantly associated with ACP1 in the brain?

The TPH2, DDC and GAD1.