Recombinant Human ACP5 protein, His-tagged
Cat.No. : | ACP5-38H |
Product Overview : | Recombinant human ACP5, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
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Description : | ACP5, also known as tartrate-resistant acid phosphatase type 5, is involved in osteopontin and bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias. |
Source : | Insect cell |
Species : | Human |
Tag : | His |
Form : | Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
Molecular Mass : | 35.1kDa (310aa) 28-40kDa (SDS-PAGE under reducing conditions) |
AA Sequence : | ATPALRFVAV GDWGGVPNAP FHTAREMANA KEIARTVQIL GADFILSLGD NFYFTGVQDI NDKRFQETFE DVFSDRSLRK VPWYVLAGNHDHLGNVSAQI AYSKISKRWN FPSPFYRLHF KIPQTNVSVA IFMLDTVTLC GNSDDFLSQQ PERPRDVKLA RTQLSWLKKQ LAAAREDYVLVAGHYPVWSI AEHGPTHCLV KQLRPLLATY GVTAYLCGHD HNLQYLQDEN GVGYVLSGAG NFMDPSKRHQ RKVPNGYLRF HYGTEDSLGGFAYVEISSKE MTVTYIEASG KSLFKTRLPR RARPHHHHHH |
Endotoxin : | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
Purity : | >95% by SDS – PAGE |
Storage : | Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5mg/ml (determined by Absorbance at 280nm) |
Gene Name : | ACP5 acid phosphatase 5, tartrate resistant [ Homo sapiens ] |
Official Symbol : | ACP5 |
Synonyms : | ACP5; acid phosphatase 5, tartrate resistant; tartrate-resistant acid phosphatase type 5; tartrate resistant acid phosphatase; TRAP; TrATPase; tartrate-resistant acid ATPase; SPENCDI; |
Gene ID : | 54 |
mRNA Refseq : | NM_001111034 |
Protein Refseq : | NP_001104504 |
MIM : | 171640 |
UniProt ID : | P13686 |
Chromosome Location : | 19p13.3-p13.2 |
Pathway : | Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Metabolism, organism-specific biosystem; Metabolism of vitamins and cofactors, organism-specific biosystem; Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem; Osteoclast Signaling, organism-specific biosystem; Osteoclast differentiation, organism-specific biosystem; |
Function : | acid phosphatase activity; ferric iron binding; ferrous iron binding; hydrolase activity; metal ion binding; |
Products Types
◆ Recombinant Protein | ||
Acp5-928M | Recombinant Mouse ACP5 protein(Met1-Pro327), His-tagged | +Inquiry |
ACP5-117R | Recombinant Rat ACP5 Protein, His (Fc)-Avi-tagged | +Inquiry |
ACP5-240H | Recombinant Human ACP5 protein(Met1-Pro320), His-tagged | +Inquiry |
ACP5-2416H | Recombinant Human ACP5 Protein, His (Fc)-Avi-tagged | +Inquiry |
Acp5-516M | Recombinant Mouse Acp5 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
ACP5-2431MCL | Recombinant Mouse ACP5 cell lysate | +Inquiry |
ACP5-2809HCL | Recombinant Human ACP5 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionthe loss of Acp5 significantly protected mice from BLM-induced lung injury and fibrosis, accompanied by a marked reduction in myofibroblast accumulation.
Alteplase, Filgrastim, and Streptozocin.
They are Metabolism; Metabolism of vitamins and cofactors; Metabolism of water-soluble vitamins and cofactors; Vitamin B2 (riboflavin) metabolism
ACP5 promoted A549 and NCI-H1975 cells undergoing epithelial-mesenchymal transition (EMT) via P53/Smad3 signaling.
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
Diseases associated with ACP5 include spondyloenchondrodysplasia with Immune dysregulation and Hairy Cell Leukemia. Among its related pathways are metabolism of water-soluble. vitamins and cofactors and Metabolism
Serum concentration of ACP5 was likely associated with decreased lung function in IPF patients.
Acp5 is upregulated by transforming growth factor-β1 (TGF-β1) in a TGF-β receptor 1 (TGFβR1)/Smad family member 3 (Smad3)-dependent manner, after which Acp5 dephosphorylates p-β-catenin at serine 33 and threonine 41, inhibiting the degradation of β-catenin and subsequently enhancing β-catenin signaling in the nucleus, which promotes the differentiation, proliferation and migration of fibroblast.
ACP5 is evaluated as osteoclast differentiation/activity markers in serum and in culture.
Acp5 deficiency protects mice from BLM-induced lung injury and fibrosis coupled with a significant reduction of fibroblast differentiation and proliferation.
Customer Reviews (5)
Write a reviewArrived prompt - good service
Much better than similar products that I've used.
Used in protein electron microscopy structure analysis.Great.
Great performance in WB :)
Patient customer service, love it.
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