Recombinant Human ACP5 protein, His-tagged
Cat.No. : | ACP5-2938H |
Product Overview : | Recombinant Human ACP5 protein, fused to His tag, was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 300mM imidazole. |
AA Sequence : | HTAREMANAKEIARTVQILGADFIL SLGDNFYFTGVQDINDKRFQETFED VFSDRSLRKVPWYVLAGNHDHLGNV SAQIAYSKISKRWNFPSPFYRLHFK IPQTNVSVAIFMLDTVTLCGNSDDF LSQQPERPRDVKLARTQLSWLKKQL AAAREDY |
Purity : | 95%, by SDS-PAGE with Coomassie Brilliant Blue staining. |
Storage : | Short-term storage: Store at 2-8°C for (1-2 weeks). Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles. |
Reconstitution : | Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage. Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage. |
Gene Name : | ACP5 acid phosphatase 5, tartrate resistant [ Homo sapiens ] |
Official Symbol : | ACP5 |
Synonyms : | ACP5; acid phosphatase 5, tartrate resistant; tartrate-resistant acid phosphatase type 5; tartrate resistant acid phosphatase; TRAP; TrATPase; tartrate-resistant acid ATPase; SPENCDI; |
Gene ID : | 54 |
mRNA Refseq : | NM_001111034 |
Protein Refseq : | NP_001104504 |
MIM : | 171640 |
UniProt ID : | P13686 |
Products Types
◆ Recombinant Protein | ||
ACP5-2416H | Recombinant Human ACP5 Protein, His (Fc)-Avi-tagged | +Inquiry |
ACP5-117R | Recombinant Rat ACP5 Protein, His (Fc)-Avi-tagged | +Inquiry |
Acp5-928M | Recombinant Mouse ACP5 protein(Met1-Pro327), His-tagged | +Inquiry |
ACP5-904H | Recombinant Human ACP5 Protein, MYC/DDK-tagged | +Inquiry |
ACP5-43R | Recombinant Rhesus Macaque ACP5 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ACP5-2809HCL | Recombinant Human ACP5 cell lysate | +Inquiry |
ACP5-2431MCL | Recombinant Mouse ACP5 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionthe loss of Acp5 significantly protected mice from BLM-induced lung injury and fibrosis, accompanied by a marked reduction in myofibroblast accumulation.
Alteplase, Filgrastim, and Streptozocin.
They are Metabolism; Metabolism of vitamins and cofactors; Metabolism of water-soluble vitamins and cofactors; Vitamin B2 (riboflavin) metabolism
ACP5 promoted A549 and NCI-H1975 cells undergoing epithelial-mesenchymal transition (EMT) via P53/Smad3 signaling.
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
Diseases associated with ACP5 include spondyloenchondrodysplasia with Immune dysregulation and Hairy Cell Leukemia. Among its related pathways are metabolism of water-soluble. vitamins and cofactors and Metabolism
Serum concentration of ACP5 was likely associated with decreased lung function in IPF patients.
Acp5 is upregulated by transforming growth factor-β1 (TGF-β1) in a TGF-β receptor 1 (TGFβR1)/Smad family member 3 (Smad3)-dependent manner, after which Acp5 dephosphorylates p-β-catenin at serine 33 and threonine 41, inhibiting the degradation of β-catenin and subsequently enhancing β-catenin signaling in the nucleus, which promotes the differentiation, proliferation and migration of fibroblast.
ACP5 is evaluated as osteoclast differentiation/activity markers in serum and in culture.
Acp5 deficiency protects mice from BLM-induced lung injury and fibrosis coupled with a significant reduction of fibroblast differentiation and proliferation.
Customer Reviews (5)
Write a reviewArrived prompt - good service
Much better than similar products that I've used.
Used in protein electron microscopy structure analysis.Great.
Great performance in WB :)
Patient customer service, love it.
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