Recombinant Human ACP5 Protein Pre-coupled Magnetic Beads

• Cat.No.: ACP5-2416H-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Human
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ACP5 acid phosphatase 5, tartrate resistant [ Homo sapiens ]
• Official Symbol: ACP5
• Synonyms: ACP5; acid phosphatase 5, tartrate resistant; tartrate-resistant acid phosphatase type 5; tartrate resistant acid phosphatase; TRAP; TrATPase; tartrate-resistant acid ATPase; SPENCDI
• Gene ID: 54
• mRNA Refseq: NM_001111034
• Protein Refseq: NP_001104504
• MIM: 171640
• UniProt ID: P13686

Reviews

08/03/2022

Arrived prompt - good service

09/11/2021

Much better than similar products that I've used.

07/02/2021

Used in protein electron microscopy structure analysis.Great.

01/10/2021

Great performance in WB :)

06/20/2018

Patient customer service, love it.

Q&As

What will happen if loss ACP5 in vivo?

the loss of Acp5 significantly protected mice from BLM-induced lung injury and fibrosis, accompanied by a marked reduction in myofibroblast accumulation.

Could please list three drugs for ACP5 gene?

Alteplase, Filgrastim, and Streptozocin.

What are four reactome pathways for ACP5 gene?

They are Metabolism; Metabolism of vitamins and cofactors; Metabolism of water-soluble vitamins and cofactors; Vitamin B2 (riboflavin) metabolism

How does ACP5 epithelial-mesenchymal transition (EMT)?

ACP5 promoted A549 and NCI-H1975 cells undergoing epithelial-mesenchymal transition (EMT) via P53/Smad3 signaling.

Can you briefly descibe the molecular function of ACP5 protein?

Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

How about the human health condition related to ACP5 gene changes?

Diseases associated with ACP5 include spondyloenchondrodysplasia with Immune dysregulation and Hairy Cell Leukemia. Among its related pathways are metabolism of water-soluble. vitamins and cofactors and Metabolism

What is the effect of ACP5 serum concentration on Idiopathic pulmonary fibrosis (IPF) patients?

Serum concentration of ACP5 was likely associated with decreased lung function in IPF patients.

What is the role of ACP5 on the process of fibroblast's cell differentiation and proliferation?

Acp5 is upregulated by transforming growth factor-β1 (TGF-β1) in a TGF-β receptor 1 (TGFβR1)/Smad family member 3 (Smad3)-dependent manner, after which Acp5 dephosphorylates p-β-catenin at serine 33 and threonine 41, inhibiting the degradation of β-catenin and subsequently enhancing β-catenin signaling in the nucleus, which promotes the differentiation, proliferation and migration of fibroblast.

What functions does ACP5 could apply when we act it as biomarks?

ACP5 is evaluated as osteoclast differentiation/activity markers in serum and in culture.

What will happen to mice if ACP5 deficiency present?

Acp5 deficiency protects mice from BLM-induced lung injury and fibrosis coupled with a significant reduction of fibroblast differentiation and proliferation.