Recombinant Human ACP6 Protein, GST-Tagged

• Cat.No.: ACP6-183H
• Product Overview: Human ACP6 full-length ORF ( NP_057445.2, 1 a.a. - 428 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 75.3 kDa
• AA Sequence: MITGVFSMRLWTPVGVLTSLAYCLH QRRVALAELQEADGQCPVDRSLLKL KMVQVVFRHGARSPLKPLPLEEQVE WNPQLLEVPPQTQFDYTVTNLAGGP KPYSPYDSQYHETTLKGGMFAGQLT KVGMQQMFALGERLRKNYVEDIPFL SPTFNPQEVFIRSTNIFRNLESTRC LLAGLFQCQKEGPIIIHTDEADSEV LYPNYQSCWSLRQRTRGRRQTASLQ PGISEDLKKVKDRMGIDSSDKVDFF ILLDNVAAEQAHNLPSCPMLKRFAR MIEQRAVDTSLYILPKEDRESLQMA VGPFLHILESNLLKAMDSATAPDKI RKLYLYAAHDVTFIPLLMTLGIFDH KWPPFAVDLTMELYQHLESKEWFVQ LYYHGKEQVPRGCPDGLCPLDMFLN AMSVYTLSPEKYHALCSQTQVMEVG NEE
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ACP6 acid phosphatase 6, lysophosphatidic [ Homo sapiens ]
• Official Symbol: ACP6
• Synonyms: ACP6; acid phosphatase 6, lysophosphatidic; lysophosphatidic acid phosphatase type 6; ACPL1; LPAP; acid phosphatase like 1; acid phosphatase-like protein 1; PACPL1
• Gene ID: 51205
• mRNA Refseq: NM_016361
• Protein Refseq: NP_057445
• MIM: 611471
• UniProt ID: Q9NPH0

Reviews

11/01/2022

I am very very happy with this recombinant protein! Was definitely worth getting the more expensive one!

01/04/2020

The website of this produce provide detaield informations to guide me use it. Great!

02/21/2019

It is a great product, worked as expected.

10/22/2018

The product is good.

03/20/2018

It works the way it's supposed to and you can't beat the price.

Q&As

What disease associated with the ACP6?

Chromosome 1q21.1 Deletion Syndrome, Duodenal Atresi, and Chromosome 1p36 Deletion Syndrome.

How about the tissue specificity of the ACP6?

Highly expressed in kidney, heart, small intestine, muscle, liver, prostate, testis, ovary and weakly expressed in thymus and colon.

What is protein differential expression in normal tissues for ACP6 gene?

This gene is overexpressed in Salivary gland, oral epithelium, and gallbladder.

List three cellular components of ACP6 gene ontology?

Cytoplasm, Mitochondrion, and Mitochondrial matrix

What are ACP6 gene related biological pathways?

Among its related pathways are Glycerophospholipid biosynthesis and Metabolism. 

What about the genomeRNAi human phenotypes for ACP6?

Increased caccinia virus infection.

What is the molecular function of the ACP6 gene?

Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.

Why ACP6 could be used as a indicator of ovarian cancer?

Lysophosphatidic acid phosphatase activity is used to detect and to quantify irregular levels of LPAs on a cell's surface.[12] LPAs are receptor-active mediators that promote cell motility, cell growth and cell survival. There is clear evidence that cancerous ovarian cells have an increased level of LPA concentrations on their cell surfaces.

What mathmatical method could be used to explore the association between ACP6 expression and a disease when ACP6 act as a biomarker?

We can apply violin plots and receiver’s operating characteristics (ROC) curves.

What does mean by ACP6 expression was obviously higher in hepatocellular carcinoma (HCC) than in non-cancer liver specimen in most RNA-seq dataset and microarrays?

It is suggested that ACP6 gene overexpressed in HCC, which present that ACP6 gene could be a clinico-pathological indicator of hepatocellular carcinoma (HCC).