Recombinant Human ACSF3 cell lysate
Cat.No. : | ACSF3-1001HCL |
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Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | ACSF3 acyl-CoA synthetase family member 3 [ Homo sapiens ] |
Official Symbol : | ACSF3 |
Synonyms : | ACSF3; acyl-CoA synthetase family member 3; acyl-CoA synthetase family member 3, mitochondrial; FLJ39242; |
Gene ID : | 197322 |
mRNA Refseq : | NM_001127214 |
Protein Refseq : | NP_001120686 |
MIM : | 614245 |
UniProt ID : | Q4G176 |
Chromosome Location : | 16q24.3 |
Function : | ATP binding; acid-thiol ligase activity; ligase activity; malonyl-CoA synthetase activity; nucleotide binding; |
Products Types
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ACSF3-194H | Recombinant Human ACSF3 Protein, GST-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionSeveral studies have found a correlation between ACSF3 gene expression and obesity, with higher ACSF3 expression levels observed in obese individuals.
ACSF3 catalyzes the activation of fatty acids for use in phospholipid synthesis, a crucial component of membrane structure and function.
ACSF3 is involved in the production of acetyl-CoA, which is a substrate for the enzyme choline acetyltransferase (ChAT) that catalyzes the formation of acetylcholine from choline and acetyl-CoA. Therefore, ACSF3 indirectly contributes to the production of acetylcholine, which is an important neurotransmitter in the nervous system.
ACSF3 catalyzes the activation of long-chain fatty acids by transferring the fatty acid to CoA, forming acyl-CoA, which can be used in various metabolic processes.
ACSF3 interacts with several proteins, including fatty acid transport proteins, diacylglycerol acyltransferases, and peroxisome proliferator-activated receptors.
Dysregulation of ACSF3 gene expression has been linked to several metabolic disorders, including obesity, insulin resistance, and type 2 diabetes.
ACSF3 has been shown to activate branched-chain fatty acids, such as phytanic acid and pristanic acid, which are derived from dietary sources or produced by gut microbiota. ACSF3 activates these fatty acids by converting them into their respective CoA esters, which can then be further metabolized in the peroxisomes.
ACSF3 gene expression is regulated by various factors, including hormones, transcription factors, and epigenetic modifications.
The expression of ACSF3 can be regulated at both the transcriptional and post-transcriptional levels. Transcriptional regulation can be mediated by factors such as peroxisome proliferator-activated receptor (PPAR) and sterol regulatory element-binding protein (SREBP), which can activate or repress the transcription of the ACSF3 gene. Post-transcriptional regulation can occur through mechanisms such as alternative splicing, microRNA-mediated degradation, and protein degradation via the ubiquitin-proteasome system.
ACSF3 is primarily localized in the mitochondria of cells, specifically in the mitochondrial outer membrane, where it functions in the beta-oxidation of fatty acids.
Customer Reviews (5)
Write a reviewThis is my go-to supplier for recombinant proteins. Always reliable and consistent.
The purity of the recombinant protein was exceptional. Very impressed.
Highly recommend this company for all your recombinant protein needs.
Quick and easy ordering process. Received my recombinant protein in a timely manner.
The recombinant protein arrived on time and in perfect condition. No issues at all.
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