Recombinant Human Actin Related Protein 2/3 Complex, Subunit 5, 16kDa, His-tagged
Cat.No. : | ARPC5-4975H |
Product Overview : | Recombinant human ARPC5 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
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Cat. No. : | ARPC5-4975H |
Description : | p16-ARC, also known as ARPC5, is a 151 amino acid subunit of the Arp2/3 complex. Thought to play a role in maintaining the integrity of Arp2/3, ARPC5 is a substrate for MAPKAPK-2 which, through phosphorylation of ARPC5, may participate in Arp2/3 regulatory functions and remodeling of the Actin cytoskeleton. Two isoforms of ARPC5 exist due to alternative splicing events. |
Concentration : | 0.5 mg/ml |
Source : | Human |
Host : | E.coli |
Form : | Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, 50% glycerol and 0.1M NaCl. |
Purity : | > 90% by SDS - PAGE |
Sequence : | 1-151 amino acids: MGSSHHHHHH SSGLVPRGSH MSKNTVSSAR FRKVDVDEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK NGVDLLMKYI YKGFESPSDN SSAMLLQWHE KALAAGGVGS IVRVLTARKT V |
Molecular Mass : | 18.4 kDa (171aa), confirmed by MALDI-TOF |
Applications : | SDS-PAGE |
Storage : | Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Gene Name : | ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa [ Homo sapiens ] |
Official Symbol : | ARPC5 |
Synonyms : | ARPC5; ARC16; p16-Arc; MGC88523; dJ127C7.3; actin related protein 2/3 complex, subunit 5, 16kDa; actin-related protein 2/3 complex subunit 5; OTTHUMP00000033266; OTTHUMP00000033267; OTTHUMP00000038626; arp2/3 complex 16 kDa subunit; Arp2/3 protein complex subunit p16; p16-ARC |
Gene ID : | 10092 |
mRNA Refseq : | NM_005717 |
Protein Refseq : | NP_005708 |
MIM : | 604227 |
UniProt ID : | O15511 |
Chromosome Location : | 1q25.3 |
Pathway : | B Cell Receptor Signaling Pathway; CDC42 signaling events; ErbB1 downstream signaling; Fc gamma R-mediated phagocytosis; Pathogenic Escherichia coli infection; RAC1 signaling pathway; Regulation of Actin Cytoskeleton; Salmonella infection; Shigellosis |
Function : | actin binding; protein binding; structural constituent of cytoskeleton |
Products Types
◆ Recombinant Protein | ||
ARPC5-455R | Recombinant Rat ARPC5 Protein, His (Fc)-Avi-tagged | +Inquiry |
ARPC5-750M | Recombinant Mouse ARPC5 Protein, His (Fc)-Avi-tagged | +Inquiry |
Arpc5-1727M | Recombinant Mouse Arpc5 Protein, Myc/DDK-tagged | +Inquiry |
ARPC5-3539H | Recombinant Human ARPC5, His-tagged | +Inquiry |
ARPC5-696H | Recombinant Human actin related protein 2/3 complex, subunit 5, 16kDa, His-tagged | +Inquiry |
◆ Lysates | ||
ARPC5-8683HCL | Recombinant Human ARPC5 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (9)
Ask a questionStudies in animal models have demonstrated that ARPC5 is essential for embryonic development. Knockout or depletion of ARPC5 leads to severe developmental defects, including abnormalities in neurodevelopment, highlighting its importance during embryogenesis.
Yes, alterations in ARPC5 expression or function can significantly impact cell migration. Since ARPC5 is a crucial component of the ARP2/3 complex involved in actin nucleation and branching, dysregulation of ARPC5 can lead to impaired cell migration and changes in cell morphology.
Currently, there is limited information available on the post-translational modifications of ARPC5. Further research is needed to investigate if ARPC5 undergoes any modifications like phosphorylation or ubiquitination, which could potentially regulate its activity and interactions.
To date, no specific diseases have been directly linked to ARPC5 mutations. However, given its involvement in actin dynamics and cellular processes, dysregulation of ARPC5 could potentially contribute to various diseases, including those involving developmental defects or abnormalities in cell migration.
Current research on ARPC5 is focused on understanding its molecular mechanisms within the ARP2/3 complex, investigating its roles in cellular processes like cell migration and adhesion, and exploring its potential implications in disease progression. Additionally, there is ongoing research to identify specific regulators or modulators of ARPC5 activity for therapeutic purposes.
ARPC5 interacts with other subunits of the ARP2/3 complex, including ARPC2 and ARPC4, forming a stable protein complex. This interaction is necessary for the proper functioning of the ARP2/3 complex in actin nucleation.
Yes, ARPC5 can play a role in cellular adhesion through its involvement in actin dynamics. The ARP2/3 complex, including ARPC5, contributes to the formation of structures like lamellipodia and focal adhesions, which are essential for cell adhesion to the extracellular matrix.
Apart from its interaction with the ARP2/3 complex, ARPC5 can also interact with other actin-binding proteins, such as cortactin and N-WASP (Neuronal Wiskott-Aldrich Syndrome Protein). These interactions contribute to the regulation of actin dynamics and various cellular processes.
Yes, emerging evidence suggests that ARPC5 may play a role in cancer progression and metastasis. The dysregulation of actin dynamics, in which ARPC5 is involved, can affect cellular processes such as invasion and migration, which are crucial for cancer metastasis.
Customer Reviews (3)
Write a reviewIts stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.
the ARPC5 protein has proven to be invaluable in protein electron microscopy structure analysis.
The ARPC5 protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.
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