Recombinant Human ACTL6B protein, GST-tagged
Cat.No. : | ACTL6B-301380H |
Product Overview : | Recombinant Human ACTL6B (40-82 aa) protein, fused to GST tag, was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
- Download
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. |
Protein length : | Thr40-Met82 |
AA Sequence : | TVGLLAAEEGGGLELEGDKEKKGKIFHIDTNALHVPRDGAEVM |
Purity : | 98%, by SDS-PAGE with Coomassie Brilliant Blue staining. |
Stability : | Store for up to 12 months at -20°C to -80°C as lyophilized powder. |
Storage : | Short-term storage: Store at 2-8°C for (1-2 weeks). Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles. |
Gene Name : | ACTL6B actin-like 6B [ Homo sapiens ] |
Official Symbol : | ACTL6B |
Synonyms : | ACTL6B; actin-like 6B; actin like 6 , ACTL6; actin-like protein 6B; BAF53B; arpNalpha; hArpN alpha; actin-like 6; BRG1-associated factor 53B; actin-related protein Baf53b; 53 kDa BRG1-associated factor B; ACTL6; |
Gene ID : | 51412 |
mRNA Refseq : | NM_016188 |
Protein Refseq : | NP_057272 |
MIM : | 612458 |
UniProt ID : | O94805 |
Products Types
◆ Recombinant Protein | ||
ACTL6B-138R | Recombinant Rat ACTL6B Protein, His (Fc)-Avi-tagged | +Inquiry |
ACTL6B-51R | Recombinant Rhesus Macaque ACTL6B Protein, His (Fc)-Avi-tagged | +Inquiry |
ACTL6B-286M | Recombinant Mouse ACTL6B Protein, His (Fc)-Avi-tagged | +Inquiry |
ACTL6B-2883Z | Recombinant Zebrafish ACTL6B | +Inquiry |
ACTL6B-223H | Recombinant Human ACTL6B Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
ACTL6B-9060HCL | Recombinant Human ACTL6B 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (21)
Ask a questionWhile the main known interacting partners of ACTL6B are within the nBAF complex, additional interactions with other proteins or complexes have not been extensively characterized.
Yes, ACTL6B is implicated in neuronal development and differentiation, as it is required for proper chromatin remodeling during neuronal maturation.
ACTL6B is evolutionarily conserved across different species, indicating its functional importance throughout evolution.
Alternative splicing variants of ACTL6B have not been widely reported in the literature. The majority of studies focus on the canonical isoform of ACTL6B.
Specific post-translational modifications of ACTL6B, such as phosphorylation or acetylation, have not been extensively studied.
ACTL6B loss is a significant cause of recessive ASD, suggesting its involvement in the development of this disorder.
ACTL6B plays a role in chromatin remodeling, gene regulation, and transcriptional control in various cell types, particularly in postmitotic neurons.
Yes, ACTL6B shares structural similarities with other actin-like proteins, including the presence of an actin fold and conserved residues involved in protein-protein interactions.
ACTL6B is primarily localized in the nucleus, where it exerts its functions in chromatin remodeling and gene regulation.
ACTL6B, as part of the nBAF complex, is involved in chromatin remodeling and gene regulation, particularly in postmitotic neurons. It plays a role in shaping the chromatin landscape and influencing cellular processes related to neuronal development and function.
ACTL6B belongs to the actin-like protein family, which comprises proteins that share structural similarities with actin but may have distinct functions and roles in cellular processes.
Yes, ACTL6B has a paralog called ACTL6A (Actin-like 6A), which shares similarities in structure and function.
Currently, there are no specific genetic disorders linked to ACTL6B mutations
The nBAF complex, including ACTL6B, plays a role in modifying the structure of chromatin, allowing for proper gene regulation and functional changes in postmitotic neurons.
ACTL6B is a component of the neuronal BRG1/brm-associated factor (nBAF) complex, which is required for chromatin remodeling specifically in postmitotic neurons.
Yes, ACTL6B interacts with other proteins within the neuronal BRG1/brm-associated factor (nBAF) complex, including various subunits involved in chromatin remodeling and gene regulation.
While the main known interacting partners of ACTL6B are within the nBAF complex, additional interactions with other proteins or complexes have not been extensively characterized.
Targeting ACTL6B or the nBAF complex could hold therapeutic potential for ASD; however, further research is needed to understand the precise mechanisms involved and to evaluate the feasibility and effectiveness of such targeting approaches.
ACTL6B is widely expressed in various tissues, but its expression is particularly prominent in the brain, where it plays a crucial role in neuronal development and function.
Impaired neuron-specific chromatin repression is proposed as a potential mechanism underlying the association between ACTL6B loss and ASD.
ACTL6B belongs to the actin-like protein family and has a conserved structure similar to actin proteins. It consists of a globular domain and a flexible C-terminal tail.
Customer Reviews (5)
Write a reviewIncreased protein expression, enhanced cell proliferation, or inhibition of specific biological processes, when using this protein.
The packaging includes proper labeling and documentation, facilitating easy identification and handling of the protein product upon arrival.
They have provided valuable technical guidance and troubleshooting assistance, helping us optimize our experimental protocols and achieve better results.
We have successfully replicated our findings using multiple batches of the protein product, indicating its reliable and consistent behavior.
The protein product is produced using state-of-the-art manufacturing techniques, ensuring consistent quality and performance.
Ask a Question for All ACTL6B Products
Required fields are marked with *
My Review for All ACTL6B Products
Required fields are marked with *
Inquiry Basket