Recombinant Human ACTL7A
Cat.No. : | ACTL7A-26590TH |
Product Overview : | Recombinant full length Human ACTL7A expressed in Saccharomyces cerevisiae; amino acids 1-435, 48.6kDa. |
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Description : | The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. |
Form : | Liquid |
Purity : | Immunogen affinity purified |
Storage buffer : | Preservative: NoneConstituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MWAPPAAIMGDGPTKKVGNQAPLQT QALQTASLRDGPAKR AVWVRHTSSEPQEPTESKAAKERPK QEVTKAVVVDLGT GYCKCGFAGLPRPTHKISTTVGKPY METAKTGDNRKET FVGQELNNTNVHLKLVNPLRHGIIV DWDTVQDIWEYLFRQEMKIAPEEHA VLVSDPPLSPHTNREKYAEMLFEAF NTP AMHIAYQSRLSMYSYGRTSGLVVEV GHGVSYVVPIYEG YPLPSITGRLDYAGSDLTAYLLGLL NSAGNEFTQDQMG IVEDIKKKCCFVALDPIEEKKVPLS EHTIRYVLPDGKEIQ LCQERFLCSEMFFKPSLIKSMQLGL HTQTVSCLNKCDI ALKRDLMGNILLCGGSTMLSGFPNR LQKELSSMCPNDT PQVNVLPERDSAVWTGGSILASLQG FQPLWVHRFEYEE HGPFFLYRRCF |
Gene Name : | ACTL7A actin-like 7A [ Homo sapiens ] |
Official Symbol : | ACTL7A |
Synonyms : | ACTL7A; actin-like 7A; actin-like protein 7A; |
Gene ID : | 10881 |
mRNA Refseq : | NM_006687 |
Protein Refseq : | NP_006678 |
MIM : | 604303 |
Uniprot ID : | Q9Y615 |
Chromosome Location : | 9q31 |
Function : | structural constituent of cytoskeleton; |
Products Types
◆ Recombinant Protein | ||
ACTL7A-139R | Recombinant Rat ACTL7A Protein, His (Fc)-Avi-tagged | +Inquiry |
ACTL7A-20C | Recombinant Cynomolgus Monkey ACTL7A Protein, His (Fc)-Avi-tagged | +Inquiry |
ACTL7A-1169H | Recombinant Human ACTL7A Protein (1-435 aa), His-SUMO-tagged | +Inquiry |
ACTL7A-287M | Recombinant Mouse ACTL7A Protein, His (Fc)-Avi-tagged | +Inquiry |
ACTL7A-1246M | Recombinant Mouse ACTL7A Protein | +Inquiry |
◆ Lysates | ||
ACTL7A-9059HCL | Recombinant Human ACTL7A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionThe altered localization of ZPBP in Actl7a KO mice suggests a potential impact on sperm-zona pellucida binding ability.
Actl7a deficiency affects the localization of ZPBP, potentially impacting sperm-zona pellucida binding. It also leads to abnormalities in PLCZ1 localization and expression, resulting in reduced calcium oscillations in oocytes.
ACTL7A is found in various tissues, including the brain, heart, liver, and skeletal muscle.
Yes, ACTL7A expression can be regulated by various factors, including signaling pathways and transcription factors.
Yes, ACTL7B is a paralog of ACTL7A, sharing sequence similarities and similar functions in chromatin remodeling.
ACTL7A is involved in nucleosome assembly, histone binding, and ATP-dependent chromatin remodeling.
It revearls the importance of ACTL7A in the complex processes involved in fertilization.
Actl7a deficiency is linked to male infertility.
The abnormal localization and expression of PLCZ1 resulted in reduced calcium oscillations in oocytes.
ACTL7A interacts with other proteins involved in chromatin remodeling, such as SMARCA4 and SMARCA2.
Yes, studies have shown that ACTL7A mutations can contribute to neurodevelopmental disorders, and further research is being conducted in this area.
There is currently no significant evidence linking ACTL7A to cancer development or progression.
The localization of ZPBP was found to be altered in the sperm of Actl7a homozygous KO male mice.
While ACTL7A itself is not currently considered a therapeutic target, understanding its role in chromatin remodeling could have implications for future therapeutic interventions.
Yes, mutations in ACTL7A have been linked to developmental disorders, including intellectual disability and autism spectrum disorder.
ACTL7A and ZPBP can form a complex that is potentially involved in acrosomal formation.
Mutations in the Actl7a gene have been reported to lead to male infertility
ACTL7A plays a role in chromatin remodeling and gene transcription regulation.
Further studies revealed that the localization and expression of the PLCZ1 protein were abnormal in misshapen sperm.
Yes, ACTL7A is involved in processes such as transcriptional regulation, DNA repair, and neuronal development.
Customer Reviews (5)
Write a reviewThe company's customer support team is highly knowledgeable and responsive, readily available to address any technical or product-related queries.
In our experiments, the protein product consistently exhibits robust and dose-dependent effects, leading to significant changes in the desired cellular responses.
Each batch of the protein product shows minimal batch-to-batch variation, providing consistent results and reducing experimental variability.
The protein product is manufactured using high-quality raw materials sourced from reputable suppliers, ensuring its purity and reliability.
The protein product is carefully packaged using appropriate storage conditions, such as freeze-drying or cold chain shipping, to maintain its stability and integrity.
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