Recombinant Human ACTL7A Protein, GST-tagged

• Cat.No.: ACTL7A-224H
• Product Overview: Human ACTL7A full-length ORF ( NP_006678.1, 1 a.a. - 435 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 75 kDa
• AA Sequence: MWAPPAAIMGDGPTKKVGNQAPLQT QALQTASLRDGPAKRAVWVRHTSSE PQEPTESKAAKERPKQEVTKAVVVD LGTGYCKCGFAGLPRPTHKISTTVG KPYMETAKTGDNRKETFVGQELNNT NVHLKLVNPLRHGIIVDWDTVQDIW EYLFRQEMKIAPEEHAVLVSDPPLS PHTNREKYAEMLFEAFNTPAMHIAY QSRLSMYSYGRTSGLVVEVGHGVSY VVPIYEGYPLPSITGRLDYAGSDLT AYLLGLLNSAGNEFTQDQMGIVEDI KKKCCFVALDPIEEKKVPLSEHTIR YVLPDGKEIQLCQERFLCSEMFFKP SLIKSMQLGLHTQTVSCLNKCDIAL KRDLMGNILLCGGSTMLSGFPNRLQ KELSSMCPNDTPQVNVLPERDSAVW TGGSILASLQGFQPLWVHRFEYEEH GPFFLYRRCF
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ACTL7A actin-like 7A [ Homo sapiens ]
• Official Symbol: ACTL7A
• Synonyms: ACTL7A; actin-like 7A; actin-like protein 7A; actin-like 7-alpha; actin-like-7-alpha
• Gene ID: 10881
• mRNA Refseq: NM_006687
• Protein Refseq: NP_006678
• MIM: 604303
• UniProt ID: Q9Y615