Recombinant Human ACTR8, His-tagged

• Cat.No.: ACTR8-19H
• Product Overview: Recombinant Human Actin-Related Protein 8/ACTR8 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Trp329) of Human ACTR8 fused with a His tag at the N-terminus.

Specification

• Description: Actin-Related Protein 8 (ACTR8) is a member of the Actin family. ACTR8 is the first example in actin family that was found to be associated with mitotic chromosomes. ACTR8 plays a vital role in the functional organization of mitotic chromosomes. This protein is a proposed core component of the chromatin remodeling INO80 complex that is involved in transcriptional regulation, DNA replication and probable DNA repair, and it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Supplied as a 0.2 μM filtered solution of PBS, 1mM DTT, pH 7.4
• AA Sequence: MNHKVHHHHHHMILMKMGFSGIVVH QESVCATYGSGLSSTCIVDVGDQKT SVCCVEDGVSHRNTR IFSWNQDISGLQDHEFQIRHPDSPA LLYQFRLGDEKLQAPMALFYPATFG IVGQKMTTLQHRSQG DPEDPHDEHYLLATQSKQEQSAKAT ADRKSASKPIGFEGDLRGQSSDLPE RLHSQEVDLGSAQGD GLMAGNDSEEALTALMSRKTAISLF EGKALGLDKAILHSIDCCSSDDTKK KMYSSILVVGGGLMF HKAQEFLQHRILNKMPPSFRRIIEN VDVITRPKDMDPRLIAWKGGAVLAC LDTTQELWIYQREWQ RFGVRMLRERAAFVW
• Endotoxin: Less than 0.1 ng/μg (1 IEU/μg).
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Storage: Store at Please minimize freeze-thaw cycles.

Reviews

02/28/2021

ACTR8 products are highly safe and do not cause allergic reactions or other adverse reactions in some people.

02/09/2020

ACTR8 is structurally stable and can be used for BCA protein quantification with great accuracy.

06/12/2018

ACTR8 under a series of changing conditions to maintain stability, stability is excellent.

Q&As

What is the full name of ACTR8 protein?

ACTR8 stands for Actin-Related Protein 8.

What is the significance of ACTR8 protein in cancer?

Aberrant expression of ACTR8 protein has been implicated in the development and progression of certain types of cancer, including breast and pancreatic cancer.

Where is ACTR8 protein expressed in the body?

ACTR8 protein is expressed in various tissues throughout the body, including the brain, heart, and skeletal muscle.

What is the potential therapeutic significance of ACTR8 protein?

ACTR8 protein is an important target for drug development, as it plays a role in various diseases and cellular processes. Understanding its structure and function can provide insights into the development of new therapies.

What is the structure of ACTR8 protein?

ACTR8 protein is a small, globular protein consisting of two domains: an N-terminal domain and a C-terminal domain.

What is the role of ACTR8 protein in cell division?

ACTR8 protein is involved in mitotic spindle assembly and chromosome segregation during cell division.

What is the function of ACTR8 protein in cells?

ACTR8 protein is a subunit of the Arp2/3 complex, which plays a key role in regulating actin cytoskeleton dynamics in cells.

How is ACTR8 protein regulated?

ACTR8 protein is regulated by various factors, including binding to other proteins and post-translational modifications such as phosphorylation.

What are the different isoforms of ACTR8 protein?

There is only one known isoform of ACTR8 protein.

What is the gene that encodes ACTR8 protein?

The gene that encodes ACTR8 protein is called ACTR8.