Recombinant Human ACVR1
Cat.No. : | ACVR1-9172H |
Product Overview : | Recombinant Human ACVR1, was expressed in Baculovirus-Insect cells |
- Specification
- Gene Information
- Related Products
Description : | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. |
Source : | Baculovirus-Insect cells |
Species : | Human |
Form : | Lyophilized. 25 mM Tris-HCl, pH7.4, 300 mM NaCl ,1 mM DTT, 5%Trehalose |
Molecular Mass : | Has a calculated molecular mass of 13.5KDa. It migrates as an approximately 17kDa band in SDS-PAGE under reducing conditions. |
Protein length : | 123 amino acids |
AA Sequence : | MVDGVMILPVLIMIALPSPSMEDEK PKVNPKLYMCVCEGLSCGNEDHCEG QQCFSSLSINDGFHVYQKGCFQVYE QGKMTCKTPPSPGQAVECCQGDWCN RNITAQLPTKGKSFPGTQNFHLE |
Purity : | >93% as determined by SDS-PAGE |
Storage : | Store it at +4℃ for short term. For long term storage, store it at -20℃ ~ -70℃ |
Reconstitution : | It is recommended to reconstitute the lyophilized ACVR1 in 0.1~0.2ml sterile and pre-cooled ddH2O, which can then be further diluted to other aqueous solutions. |
Gene Name : | ACVR1 activin A receptor, type I [ Homo sapiens ] |
Official Symbol : | ACVR1 |
Synonyms : | ACVR1; activin A receptor, type I; ACVRLK2; activin receptor type-1; ACVR1A; ALK2; SKR1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; FOP; TSRI; ACTRI; |
Gene ID : | 90 |
mRNA Refseq : | NM_001105 |
Protein Refseq : | NP_001096 |
MIM : | 102576 |
UniProt ID : | Q04771 |
Chromosome Location : | 2q23-q24 |
Pathway : | ALK1 pathway, organism-specific biosystem; ALK1 signaling events, organism-specific biosystem; ALK2 signaling events, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem; |
Function : | ATP binding; SMAD binding; activin binding; contributes_to activin receptor activity, type I; follistatin binding; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor activity; receptor signaling protein serine/threonine kinase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; transmembrane receptor protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
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ACVR1-0158H | Recombinant Human ACVR1 Protein (T172-C509), Tag Free | +Inquiry |
Acvr1-775M | Active Recombinant Mouse Acvr1 protein(Met1-Glu123), His&hFc-tagged | +Inquiry |
ACVR1-527H | Active Recombinant Human ACVR1 Protein, His/Fc-tagged | +Inquiry |
ACVR1-1022H | Recombinant Human ACVR1 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
ACVR1-1232CCL | Recombinant Cynomolgus ACVR1 cell lysate | +Inquiry |
ACVR1-967CCL | Recombinant Canine ACVR1 cell lysate | +Inquiry |
ACVR1-2686MCL | Recombinant Mouse ACVR1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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