Recombinant Human ACVR1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | ACVR1-5028H |
Product Overview : | ACVR1 MS Standard C13 and N15-labeled recombinant protein (NP_001096) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 57.15 kDa |
AA Sequence : | MVDGVMILPVLIMIALPSPSMEDEK PKVNPKLYMCVCEGLSCGNEDHCEG QQCFSSLSINDGFHVYQKGCFQVYE QGKMTCKTPPSPGQAVECCQGDWCN RNITAQLPTKGKSFPGTQNFHLEVG LIILSVVFAVCLLACLLGVALRKFK RRNQERLNPRDVEYGTIEGLITTNV GDSTLADLLDHSCTSGSGSGLPFLV QRTVARQITLLECVGKGRYGEVWRG SWQGENVAVKIFSSRDEKSWFRETE LYNTVMLRHENILGFIASDMTSRHS STQLWLITHYHEMGSLYDYLQLTTL DTVSCLRIVLSIASGLAHLHIEIFG TQGKPAIAHRDLKSKNILVKKNGQC CIADLGLAVMHSQSTNQLDVGNNPR VGTKRYMAPEVLDETIQVDCFDSYK RVDIWAFGLVLWEVARRMVSNGIVE DYKPPFYDVVPNDPSFEDMRKVVCV DQQRPNIPNRWFSDPTLTSLAKLMK ECWYQNPSARLTALRIKKTLTKIDN SLDKLKTDCTRTRPLEQKLISEEDL AANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | ACVR1 activin A receptor type 1 [ Homo sapiens (human) ] |
Official Symbol : | ACVR1 |
Synonyms : | ACVR1; activin A receptor, type I; ACVRLK2; activin receptor type-1; ACVR1A; ALK2; SKR1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; FOP; TSRI; ACTRI; |
Gene ID : | 90 |
mRNA Refseq : | NM_001105 |
Protein Refseq : | NP_001096 |
MIM : | 102576 |
UniProt ID : | Q04771 |
Products Types
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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