Recombinant Human ACVRL1
Cat.No. : | ACVRL1-26593TH |
Product Overview : | Recombinant human ACVRL1 fragment was expressed by baculovirus in Sf9 insect cells using an N-terminal tag, 64kDa. |
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Description : | This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. |
Biological activity : | The specific activity of ACVRL1-26593TH was determined to be 22 nmol /min/mg. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 GS domain.Contains 1 protein kinase domain. |
Gene Name : | ACVRL1 activin A receptor type II-like 1 [ Homo sapiens ] |
Official Symbol : | ACVRL1 |
Synonyms : | ACVRL1; activin A receptor type II-like 1; ACVRLK1, ORW2; serine/threonine-protein kinase receptor R3; ALK1; HHT; HHT2; |
Gene ID : | 94 |
mRNA Refseq : | NM_000020 |
Protein Refseq : | NP_000011 |
MIM : | 601284 |
Uniprot ID : | P37023 |
Chromosome Location : | 12q11-q14 |
Pathway : | ALK1 pathway, organism-specific biosystem; ALK1 signaling events, organism-specific biosystem; Id Signaling Pathway, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem; |
Function : | ATP binding; SMAD binding; activin binding; activin receptor activity, type I; contributes_to activin receptor activity, type I; |
Products Types
◆ Recombinant Protein | ||
Acvrl1-2M | Recombinant Mouse Acvrl1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ACVRL1-72H | Recombinant Human ACVRL1 Protein, His-tagged | +Inquiry |
Acvrl1-530M | Recombinant Mouse Acvrl1 Protein, MYC/DDK-tagged | +Inquiry |
ACVRL1-1186C | Active Recombinant Cynomolgus ACVRL1 protein(Met1-Gln118), His-tagged | +Inquiry |
Acvrl1-2333M | Active Recombinant Mouse Acvrl1 protein(Met1-Pro119), His&hFc-tagged | +Inquiry |
◆ Lysates | ||
ACVRL1-994CCL | Recombinant Canine ACVRL1 cell lysate | +Inquiry |
ACVRL1-3093MCL | Recombinant Mouse ACVRL1 cell lysate | +Inquiry |
ACVRL1-1191CCL | Recombinant Cynomolgus ACVRL1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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