| Description : |
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
12.3 kDa |
| Protein Length : |
503 |
| AA Sequence : |
MTLGSPRKGLLMLLMALVTQGDPVK PSRGPLVTCTCESPHCKGPTCRGAW CTVVLVREEGRHPQEHRGCGNLHRE LCRGRPTEFVNHYCCDSHLCNHNVS LVLEATQPPSEQPGTDGQLALILGP VLALLALVALGVLGLWHVRRRQEKQ RGLHSELGESSLILKASEQGDSMLG DLLDSDCTTGSGSGLPFLVQRTVAR QVALVECVGKGRYGEVWRGLWHGES VAVKIFSSRDEQSWFRETEIYNTVL LRHDNILGFIASDMTSRNSSTQLWL ITHYHEHGSLYDFLQRQTLEPHLAL RLAVSAACGLAHLHVEIFGTQGKPA IAHRDFKSRNVLVKSNLQCCIADLG LAVMHSQGSDYLDIGNNPRVGTKRY MAPEVLDEQIRTDCFESYKWTDIWA FGLVLWEIARRTIVNGIVEDYRPPF YDVVPNDPSFEDMKKVVCVDQQTPT IPNRLAADPVLSGLAQMMRECWYPN PSARLTALRIKKTLQKISNSPEKPK VIQ |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
