Recombinant Human Acyl-CoA Dehydrogenase, Long Chain, His-tagged
Cat.No. : | ACADL-1278H |
Product Overview : | Recombinant human ACADL protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
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Cat. No. : | ACADL-1278H |
Description : | ACADL belongs to the acyl-CoA dehydrogenase family, existing as a homotetramer. It is involved in the catabolism of fatty acids and amino acids and they provide a major source of energy for the heart and skeletal muscle. Defect in the gene encoding ACADL leads to non-ketotic hypoglycemia and hypotonia, muscle weakness. |
Form : | Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 30% glycerol, 0.1 M NaCl. |
Molecular Weight : | 46.7 kDa (421aa), confirmed by MALDI-TOF |
Purity : | > 85 % by SDS-PAGE |
Concentration : | 1 mg/ml (determined by Bradford) |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MGGEERLETP SAKKLTDIGI RRIFSPEHDI FRKSVRKFFQ EEVIPHHSEW EKAGEVSREV WEKAGKQGLL GVNIAEHLGG IGGDLYSAAI VWEEQAYSNC SGPGFSIHSG IVMSYITNHG SEEQIKHFIP QMTAGKCIGA IAMTEPGAGS DLQGIKTNAK KDGSDWILNG SKVFISNGSL SDVVIVVAVT NHEAPSPAHG ISLFLVENGM KGFIKGRKLH KMGLKAQDTA ELFFEDIRLP ASALLGEENK GFYYIMKELP QERLLIADVA ISASEFMFEE TRNYVKQRKA FGKTVAHLQT VQHKLAELKT HICVTRAFVD NCLQLHEAKR LDSATACMAK YWASELQNSV AYDCVQLHGG WGYMWEYPIA KAYVDARVQP IYGGTNEIMK ELIAREIVFD K |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Pathways : | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Fatty acid metabolism; Fatty acid, triacylglycerol, and ketone body metabolism; Metabolic pathways; Metabolism of lipids and lipoproteins; Mitochondrial Fatty Acid Beta-Oxidation; PPAR signaling pathway; mitochondrial fatty acid beta-oxidation of saturated fatty acids |
Gene Name : | ACADL acyl-CoA dehydrogenase, long chain [ Homo sapiens ] |
Official Symbol : | ACADL |
Synonyms : | ACADL; acyl-CoA dehydrogenase, long chain; long-chain specific acyl-CoA dehydrogenase, mitochondrial; OTTHUMP00000163937; acyl-Coenzyme A dehydrogenase, long chain; LCAD; ACAD4; FLJ94052 |
Gene ID : | 33 |
mRNA Refseq : | NM_001608 |
Protein Refseq : | NP_001599 |
MIM : | 609576 |
UniProt ID : | P28330 |
Chromosome Location : | 2q34-q35 |
Function : | acyl-CoA dehydrogenase activity; fatty-acyl-CoA binding; flavin adenine dinucleotide binding; long-chain-acyl-CoA dehydrogenase activity; palmitoyl-CoA oxidase activity |
Products Types
◆ Recombinant Protein | ||
Acadl-22M | Recombinant Mouse Acadl Protein, His&GST-tagged | +Inquiry |
ACADL-237M | Recombinant Mouse ACADL Protein, His (Fc)-Avi-tagged | +Inquiry |
ACADL-14C | Recombinant Cynomolgus Monkey ACADL Protein, His (Fc)-Avi-tagged | +Inquiry |
ACADL-92R | Recombinant Rat ACADL Protein, His (Fc)-Avi-tagged | +Inquiry |
ACADL-264C | Recombinant Cynomolgus ACADL Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ACADL-4HCL | Recombinant Human ACADL lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionThe activity of acyl-CoA dehydrogenase long chain contributes to the breakdown of long-chain fatty acids to produce energy in cells.
The expression of acyl-CoA dehydrogenase long chain is regulated by a variety of factors, including gene expression and protein degradation pathways.
Acyl-CoA dehydrogenase long chain protein is located in the mitochondrial matrix.
There are currently no known inhibitors or activators of acyl-CoA dehydrogenase long chain protein.
Acyl-CoA dehydrogenase long chain protein has specificity for long-chain fatty acyl-CoA substrates.
Research is ongoing to further understand the function and regulation of acyl-CoA dehydrogenase long chain protein, as well as its role in metabolic disorders.
Acyl-CoA dehydrogenase long chain plays a key role in energy metabolism and fatty acid oxidation in cells.
Acyl-CoA dehydrogenase long chain protein catalyzes the first step in the 尾-oxidation of long-chain fatty acids.
Mutations in this protein are associated with a variety of metabolic disorders, including long-chain acyl-CoA dehydrogenase deficiency.
Acyl-CoA dehydrogenase long chain protein has a flavin adenine dinucleotide (FAD)-binding domain that is essential for its function.
Customer Reviews (2)
Write a reviewProvides accurate and reproducible quantification of the target protein in mass spectrometry analysis.
Shows excellent performance in detecting and quantifying the expression levels of recombinant proteins in protein expression analysis.
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