Recombinant Human ADAT3 Protein, His-tagged

• Cat.No.: ADAT3-1144H
• Product Overview: Recombinant human ADAT3 protein, fused to His tag at N-terminus, was expressed in E. coli.

Specification

• Description: This gene encodes a subunit of a tRNA-specific adenosine deaminase. This heterodimeric enzyme converts adenosine to inosine in the tRNA anticodon. A mutation in this gene causes a syndrome characterized by intellectual disability and strabismus. This gene shares its 5' exon with the overlapping gene, secretory carrier membrane protein 4 (Gene ID: 113178). [provided by RefSeq, Jul 2016].
• Source: E. coli
• Species: Human
• Tag: His
• Form: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.
• Molecular Mass: 37.9 kDa
• Purity: >50 ug/mL as determined by microplate BCA method
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: ADAT3 adenosine deaminase, tRNA-specific 3 [ Homo sapiens ]
• Official Symbol: ADAT3
• Synonyms: FWP005; MRT36; MST121; MSTP121; S863-5; TAD3
• Gene ID: 113179
• mRNA Refseq: NM_138422
• Protein Refseq: NP_612431
• UniProt ID: Q96EY9

Q&As

Are there any drugs that target ADAT3 currently in clinical development?

To the best of our knowledge, there are currently no drugs that specifically target ADAT3 in clinical development. However, there may be drugs that indirectly affect ADAT3 function or expression, and further research may identify potential drug targets within the ADAT3 pathway.

Is ADAT3 protein used in diagnostic testing?

ADAT3 protein is not currently used in diagnostic testing, although it is an active area of research. However, ADAT3 expression levels have been shown to correlate with prognosis and tumor progression in certain types of cancer, suggesting that it may have diagnostic value in the future.

Is ADAT3 involved in the immune response?

There is some evidence to suggest that ADAT3 may play a role in regulating the immune response, although the extent of its involvement is still not fully understood. ADAT3 has been shown to regulate the expression of genes involved in cytokine signaling, which is essential for coordinating the immune response to infections and other invaders. Further research is needed to fully understand the role of ADAT3 in the immune system.

Are there any current FDA-approved drugs that target ADAT3?

There are currently no FDA-approved drugs that target ADAT3 specifically. However, some existing drugs may indirectly affect ADAT3 function or expression. For example, FDA-approved cancer drugs such as gemcitabine have been shown to inhibit the expression of ADAT3 in cancer cells.

Is ADAT3 expressed in all tissues and cells?

While ADAT3 is expressed in many different tissues and cell types, its expression is not ubiquitous and can vary depending on the specific context. For example, ADAT3 is expressed at higher levels in certain types of cancers and immune cells, suggesting that it may play a more prominent role in these contexts.

Is ADAT3 involved in neurodegenerative diseases?

While ADAT3 has not been directly implicated in any specific neurodegenerative diseases, its role in regulating the expression of genes involved in nervous system function and development suggests that it could potentially play a role in these diseases. Further research is needed to fully understand the extent of ADAT3's involvement in neurodegenerative diseases.

Can ADAT3 be used for gene therapy?

While ADAT3 itself is not typically used in gene therapy, its role in RNA editing makes it a potentially useful target for gene therapy. By editing RNA transcripts to alter the amino acid sequence of proteins, ADAT3 could be used to correct genetic mutations that cause or contribute to disease.

Can ADAT3 be used as a drug target for other diseases besides cancer?

It is possible that ADAT3 could be used as a drug target for other diseases besides cancer, particularly those involving dysregulated RNA editing. However, more research is needed to understand the full range of ADAT3's roles and interactions within cells and tissues before it can be considered a viable drug target for other diseases.

Is ADAT3 involved in drug resistance in cancer cells?

There is some evidence suggesting that ADAT3 may play a role in drug resistance in certain types of cancer cells. Specifically, ADAT3 has been shown to regulate the expression of genes involved in drug efflux, which can contribute to resistance to chemotherapy. Further research is needed to fully understand the extent of ADAT3's involvement in drug resistance.

What are the potential therapeutic applications of ADAT3 protein?

The potential therapeutic applications of ADAT3 protein include targeted cancer therapy, where inhibition of ADAT3 has been shown to inhibit tumor growth in preclinical models. Additionally, modulating the function of ADAT3 could have therapeutic benefits in other diseases where RNA editing is dysregulated, such as neurological disorders.

How is ADAT3 protein produced for research and therapeutic purposes?

ADAT3 protein can be produced using recombinant DNA technology, which involves cloning and expressing the ADAT3 gene in a host cell such as bacteria or yeast. The protein can then be purified and used for research or therapeutic purposes.

Could ADAT3 be used as a target for cancer therapy?

Yes, ADAT3 has been identified as a potential target for cancer therapy due to its role in promoting cancer cell growth and survival. Inhibition of ADAT3 activity could be a strategy for developing new cancer treatments.

Are there any diagnostic tests that use ADAT3 protein?

Currently, there are no diagnostic tests that directly measure ADAT3 protein levels or activity. However, research is ongoing to investigate the potential use of ADAT3 as a biomarker for certain types of cancer.