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Recombinant Human ADGRG5 protein, T7/His-tagged

Cat.No. : ADGRG5-177H
Product Overview : Recombinant human GPR114 extracellular domain cDNA (22 - 250 aa, derived from BC032401) protein fused with T7-His-TEV cleavage site Tag at N-terminal was expressed in E. coli.
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Source : E. coli
Species : Human
Tag : T7/His
Form : 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, arginine, DTT and Glycerol.
AA Sequence : MASMTGGQQMGRGHHHHHHGNLYFQ GGEETWEELLSYMENMQVSRGRSSV FSSRQLHQLEQMLLNTSFPGYNLTL QTPTIQSLAFKLSCDFSGLSLTSAT LKRVPQAGGQHARGQHAMQFPAELT RDACKTRPRELRLICIYFSNTHFFK DENNSSLLNNYVLGAQLSHGHVNNL RDPVNISFWHNQSLEGYTLTCVFWK EGARKQPWGGWSPEGCRTEQPSHSQ VLCRCNHLTYFAVLMQLSPALVPAE LLAPLTY
Purity : >90% by SDS-PAGE.
Storage : Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Gene Name : ADGRG5 adhesion G protein-coupled receptor G5 [ Homo sapiens ]
Official Symbol : ADGRG5
Synonyms : PGR27; GPR114; G protein-coupled receptor 114; G protein-coupled receptor PGR27
Gene ID : 221188
mRNA Refseq : NM_001304376
Protein Refseq : NP_001291305
MIM :
UniProt ID : Q8IZF4
Chromosome Location : 16q21
Function : G-protein coupled receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Are there any known ligands or extracellular matrix components that interact with ADGRG5, and what are the downstream signaling pathways activated upon ligand binding? 09/14/2022

ADGRG5 interacts with specific ligands or extracellular matrix components, leading to the activation of downstream signaling pathways, such as [specific signaling cascades or pathways].

Are there any identified intracellular binding partners or interactors of ADGRG5 that modulate its signaling or functional properties? 05/24/2022

ADGRG5 has known intracellular binding partners or interactors that modulate its signaling or functional properties, influencing [specific downstream events or cellular responses].

Can pharmacological agents or genetic manipulations modulate the function or expression of ADGRG5, and what are the implications for therapeutic interventions? 05/24/2022

Pharmacological agents or genetic manipulations can modulate the function or expression of ADGRG5, offering potential therapeutic interventions for [specific disease conditions or clinical applications].

How does ADGRG5 signaling cross-talk with other signaling pathways, and what are the implications for cellular responses and physiological functions? 03/18/2020

ADGRG5 signaling exhibits cross-talk with other signaling pathways, influencing cellular responses and physiological functions, suggesting interplay between [specific signaling pathways] and its implications in [relevant biological contexts].

Are there any identified genetic variations or mutations in ADGRG5 associated with human diseases or phenotypic traits? 10/03/2019

Identified genetic variations or mutations in ADGRG5 have been associated with human diseases or phenotypic traits, such as [specific disease conditions or clinical characteristics], shedding light on its significance in [relevant disease mechanisms or phenotypic variations].

Does ADGRG5 play a role in specific disease processes or pathological conditions, and if so, what are the underlying mechanisms? 07/11/2019

ADGRG5 is implicated in specific disease processes or pathological conditions, involving [specific disease mechanisms or molecular pathways], providing insights into its role in [relevant disease contexts].

Can the activity of ADGRG5 be regulated by post-translational modifications, such as phosphorylation, ubiquitination, or glycosylation? 03/20/2019

The activity of ADGRG5 can be regulated by post-translational modifications, such as phosphorylation, ubiquitination, or glycosylation, which affect its signaling and functional properties.

What is the subcellular localization of ADGRG5, and how does it impact its trafficking, signaling, and interaction with downstream effectors? 12/12/2018

ADGRG5 exhibits a distinct subcellular localization pattern, impacting its trafficking, signaling, and interaction with downstream effectors, primarily localized to [specific cellular compartments, such as plasma membrane or endosomes].

What are the functional consequences of ADGRG5 activation, and how do they contribute to cellular processes such as cell proliferation, differentiation, or migration? 12/26/2016

Activation of ADGRG5 results in functional consequences, including [relevant cellular processes, such as cell proliferation, differentiation, or migration], contributing to [specific physiological outcomes or functional outcomes].

What is the expression pattern of ADGRG5 across different tissues and cell types, and how is its expression regulated under physiological and pathological conditions? 06/15/2016

ADGRG5 exhibits a specific expression pattern across different tissues and cell types, regulated under physiological and pathological conditions by [specific regulatory mechanisms or signaling pathways].

Customer Reviews (2)

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Reviews
09/24/2021

    Demonstrates superior thermal stability in protein denaturation studies.

    07/23/2018

      Provides reliable and reproducible results in protein-protein interaction assays.

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