Recombinant Human ADIPOR2, GST-tagged
Cat.No. : | ADIPOR2-210H |
Product Overview : | Human ADIPOR2 full-length ORF ( NP_078827.2, 1 a.a. - 386 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin. |
Source : | Wheat germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 70.3 kDa |
AA Sequence : | MNEPTENRLGCSRTPEPDIRLRKGH QLDGTRRGDNDSHQGDLEPILEASV LSSHHKKSSEEHEYSDEAPQEDEGF MGMSPLLQAHHAMEKMEEFVCKVWE GRWRVIPHDVLPDWLKDNDFLLHGH RPPMPSFRACFKSIFRIHTETGNIW THLLGCVFFLCLGIFYMFRPNISFV APLQEKVVFGLFFLGAILCLSFSWL FHTVYCHSEGVSRLFSKLDYSGIAL LIMGSFVPWLYYSFYCNPQPCFIYL IVICVLGIAAIIVSQWDMFATPQYR GVRAGVFLGLGLSGIIPTLHYVISE GFLKAATIGQIGWLMLMASLYITGA ALYAARIPERFFPGKCDIWFHSHQL FHIFVVAGAFVHFHGVSNLQEFRFM IGGGCSEEDAL |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot; Antibody Production; Protein Array |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ADIPOR2 adiponectin receptor 2 [ Homo sapiens (human) ] |
Official Symbol : | ADIPOR2 |
Synonyms : | ADIPOR2; PAQR2; ACDCR2; adiponectin receptor 2; progestin and adipoQ receptor family member II |
Gene ID : | 79602 |
mRNA Refseq : | NM_024551 |
Protein Refseq : | NP_078827 |
MIM : | 607946 |
UniProt ID : | Q86V24 |
Chromosome Location : | 12p13.31 |
Pathway : | AMPK signaling; Adipocytokine signaling pathway |
Function : | hormone binding; identical protein binding; protein heterodimerization activity |
Products Types
◆ Recombinant Protein | ||
ADIPOR2-77R | Recombinant Rhesus Macaque ADIPOR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ADIPOR2-9429H | Recombinant Human ADIPOR2 protein, His-tagged | +Inquiry |
Adipor2-556R | Recombinant Rat Adipor2 protein, His & T7-tagged | +Inquiry |
ADIPOR2-9427H | Recombinant Human ADIPOR2, GST-tagged | +Inquiry |
ADIPOR2-555H | Recombinant Human ADIPOR2 protein, His & GST-tagged | +Inquiry |
◆ Lysates | ||
ADIPOR2-9009HCL | Recombinant Human ADIPOR2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (12)
Ask a questionSeveral genetic mutations have been identified in the ADIPOR2 gene that have been linked to obesity and metabolic disorders. However, these mutations are relatively rare and more research is needed to understand their implications for health.
Various techniques are used to study ADIPOR2, including molecular biology techniques such as PCR and Western blotting, imaging techniques such as immunofluorescence and confocal microscopy, and animal models such as knockout mice.
ADIPOR2 expression is regulated by various factors, including adiponectin levels, insulin sensitivity, and inflammation. Certain dietary factors, such as polyphenols and omega-3 fatty acids, have also been shown to increase ADIPOR2 expression.
Studies have suggested that ADIPOR2 may have a role in regulating bone metabolism and bone formation. This is because ADIPOR2 activation stimulates osteogenic differentiation and mineralization in bone cells. Therefore, targeting ADIPOR2 activation may be a potential therapeutic strategy for osteoporosis and other bone-related disorders.
As genetic mutations in the ADIPOR2 gene have been associated with obesity and metabolic disorders, targeting ADIPOR2 could potentially be used in personalized medicine to develop treatments for individuals with specific mutations. However, further research is needed to determine the feasibility and efficacy of this approach.
One of the main challenges in developing ADIPOR2-targeted therapies is the potential side effects associated with targeting a receptor that has multiple functions throughout the body. Additionally, more research is needed to fully understand the signaling pathways and mechanisms of ADIPOR2 activation, which could impact the development of effective and safe therapies.
Yes, ADIPOR2 activation has been shown to have beneficial effects on cardiovascular health. This includes improving vascular function, reducing oxidative stress, and decreasing inflammation. Therefore, targeting ADIPOR2 activation may be a viable therapeutic strategy for cardiovascular diseases such as atherosclerosis and hypertension.
ADIPOR2 has been suggested to play a role in insulin resistance by regulating glucose uptake and lipid oxidation. In insulin-resistant individuals, ADIPOR2 expression and activation may be reduced, leading to impaired glucose uptake and metabolism. Therefore, targeting ADIPOR2 activation may be beneficial in improving insulin sensitivity.
There is some evidence to suggest that ADIPOR2 may play a role in cancer development and progression. Studies have found that ADIPOR2 expression is reduced in certain types of cancer, but more research is needed to fully understand its implications for cancer.
There is growing interest in ADIPOR2 as a potential therapeutic target for metabolic disorders such as obesity and type 2 diabetes. However, more research is needed to fully understand the mechanisms of ADIPOR2 and its potential as a drug target.
As ADIPOR2 has various functions throughout the body, targeting it for therapy may have potential side effects. These could include changes in glucose and lipid metabolism, as well as effects on the central nervous system.
Recent studies have suggested a potential link between ADIPOR2 and neurodegenerative diseases such as Alzheimer's and Parkinson's disease. This is because ADIPOR2 activation may have a protective effect on neurons by reducing oxidative stress and inflammation. However, more research is needed to fully understand the role of ADIPOR2 in neurodegenerative diseases.
Customer Reviews (5)
Write a reviewADIPOR2 protein and manufacturer's support have been instrumental in my research progress, and I highly recommend their products to fellow researchers.
I am pleased to report that the ADIPOR2 protein provided by the manufacturer is of exceptional quality and perfectly meets the needs of my ongoing experiments.
the excellent technical support and customer service provided by the manufacturer have been very helpful in resolving any issues I encountered during the experimental process.
The combination of high-quality protein, expert technical support, and commitment to scientific excellence has made them an invaluable partner in my research endeavors.
The purity and consistency of the ADIPOR2 protein are evident in the reproducible results I have obtained in my experiments.
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