Recombinant Human ADNP protein, His & GST-tagged

• Cat.No.: ADNP-1701H
• Product Overview: Recombinant Human ADNP aa. (Ala528~Thr782 (Accession # Q9H2P0)) fused with N-terminal His & GST tag was produced in E. coli cells.

Specification

• Description: Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described.
• Source: E. coli
• Species: Human
• Tag: His & GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 58.6kDa
• Protein length: Ala528~Thr782 (Accession # Q9H2P0)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >90%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Isoelectric Point: 8.5

Gene Information

• Gene Name: ADNP activity dependent neuroprotector homeobox [ Homo sapiens (human) ]
• Official Symbol: ADNP
• Synonyms: ADNP; activity dependent neuroprotector homeobox; ADNP1; HVDAS; MRD28; activity-dependent neuroprotector homeobox protein; ADNP homeobox 1; activity-dependent neuroprotective protein; activity-dependent neuroprotector
• Gene ID: 23394
• mRNA Refseq: NM_001282531.2
• Protein Refseq: NP_001269460.1
• UniProt ID: Q9H2P0

Reviews

11/28/2022

I am grateful for the access to such exceptional resources and look forward to continued success in our research endeavors.

02/06/2022

Its purity and stability characteristics are exceptional, making it highly suitable for our experimental needs.

08/23/2020

the manufacturer's technical support team has been extremely helpful in providing solutions to any issues we encounter during our experiments.

02/17/2017

Based on my research and prior experience, I can confidently state that the protein we are working with is of extremely high quality.

Q&As

Can ADNP proteins be used as a diagnostic tool for autism?

Currently, ADNP mutations are not routinely used as a diagnostic tool for ASD. However, further research may elucidate ADNP's involvement in autism and its potential for diagnostic purposes.

How do ADNP mutations impact brain development?

Research suggests that ADNP mutations can disrupt normal brain development, leading to various neurological disorders. ADNP is involved in regulating the expression of genes that are crucial for the development and function of neurons, including genes that control synaptic plasticity, dendrite branching, and axon extension.

Can ADNP be used as a therapeutic target for cancer?

ADNP has been proposed as a potential therapeutic target for certain types of cancer. However, more research is needed to elucidate ADNP's role in cancer and its potential as a therapeutic target.

Are there any ongoing clinical trials for ADNP-associated disorders?

Currently, there are no known clinical trials specifically targeting ADNP-associated disorders. However, there are clinical trials for other disorders that may be relevant for individuals with ADNP mutations, such as ASD and intellectual disability.

Are there any existing drugs that target ADNP?

There are currently no drugs that specifically target ADNP. However, some drugs that modulate ADNP activity indirectly, such as valproic acid and FK506, have been investigated for their potential therapeutic effects in various neurological disorders.

What are ADNP proteins and what do they do in the body?

ADNP (activity-dependent neuroprotective protein) is a neuroprotective protein that plays a critical role in brain development and function. It is involved in various biological processes, such as DNA repair, transcriptional regulation, and cell proliferation.

What are the challenges in researching ADNP?

One of the main challenges in researching ADNP is its complex role in various biological processes, including epigenetic regulation, chromatin remodeling, and transcriptional regulation. This complexity makes it difficult to determine the specific mechanisms underlying ADNP's effects on neuronal development and function.

How is ADNP related to other genes associated with autism spectrum disorder?

ADNP is one of several genes that have been identified as ASD risk genes. Other ASD risk genes include SHANK3, SYNGAP1, and CHD8. These genes are involved in various aspects of brain development and function, such as synapse formation and maintenance, neuronal signaling, and chromatin regulation.

What are the challenges in developing treatments for ADNP-associated disorders?

One of the main challenges in developing treatments for ADNP-associated disorders is the complexity of ADNP's role in neuronal development and function. ADNP is involved in many different biological processes, including chromatin remodeling, transcriptional regulation, and epigenetic modification. Developing targeted therapies that modulate ADNP activity without disrupting these other biological processes is challenging.

What are the challenges in developing ADNP-based therapies?

One of the main challenges in developing ADNP-based therapies is understanding the complex nature of ADNP's involvement in various biological processes, as well as its functional role in different disease states. Additionally, delivering ADNP-based therapies to specific target tissues or cells may be challenging.

Can ADNP be used as a treatment for neurodegenerative diseases?

ADNP has shown potential as a therapeutic target for a range of neurodegenerative diseases, including AD and Parkinson's disease. However, further research is needed before ADNP-based treatments can become a clinical reality.

How can ADNP research advance our understanding of brain development and function?

Studying ADNP's involvement in brain development and function can provide insights into the complex molecular mechanisms that underlie these processes. Understanding the role of ADNP in neuronal development and synaptic plasticity could pave the way for new treatments for neurological disorders such as autism and Alzheimer's disease. Additionally, ADNP research may contribute to our understanding of the genetic and environmental factors that shape brain development and function.

How are ADNP mutations inherited?

ADNP mutations can be inherited in an autosomal dominant or sporadic pattern. In autosomal dominant inheritance, a single copy of the mutated ADNP gene from one parent is sufficient to cause the disorder. In sporadic cases, the mutation occurs randomly and is not inherited from either parent.