Recombinant Human ADP-Ribosylation Factor-Like 2 Binding Protein, His-tagged
Cat.No. : | ARL2BP-6904H |
Product Overview : | Recombinant human GCA protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. MW: 20.9 kDa. |
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Description : | ARL2BP is an effector of ADP-ribosylation factor-like 2(ARL2) that is essential for nuclear retention of STAT3. This protein binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. Though predominantly cytosolic, ARL2BP can enter the mitochondria and bind the adenine nucleotide transporter when bound to ARL2. Thus it may also be involved in mitochondria transport and apoptosis. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 10% Glycerol. |
Molecular Mass : | 20.9 kDa (183aa), confirmed by MALDI-TOF |
Protein length : | 1-163aa |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MDALEGESFA LS FSSASDAE FDAVVGYLED IIMDDEFQLL QRNFMDKYYL EFEDTEENKL IYTPIFNEYI SLVEKYIEEQ LLQRIPEFNM AAFTTTLQHH KDEVAGDIFD MLLTFTDFLA FKEMFLDYRA EKEGRGLDLS SGLVVTSLCK SSSLPASQNN LRH |
Purity : | >90% by SDS-PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at 4℃ short term (1-2 weeks). For long term storage, aliquot and store at -20℃ or -70℃. Avoid repeated freezing and thawing cycles. |
Concentration : | 1.0 mg/ml (determined by Bradford assay) |
Gene Name : | ARL2BP ADP-ribosylation factor-like 2 binding protein [ Homo sapiens ] |
Official Symbol : | ARL2BP |
Synonyms : | ARL2BP; ADP-ribosylation factor-like 2 binding protein; ADP-ribosylation factor-like protein 2-binding protein; BART; BART1; binder of Arl2; binder of Arl Two; binder of ARF2 protein 1; ARF-like 2-binding protein; Arf-like 2 binding protein BART1; |
Gene ID : | 23568 |
mRNA Refseq : | NM_012106 |
Protein Refseq : | NP_036238 |
UniProt ID : | Q9Y2Y0 |
Chromosome Location : | 16q13 |
Function : | protein binding; small GTPase regulator activity; transcription coactivator activity; |
Products Types
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ARL2BP-229R | Recombinant Rhesus Macaque ARL2BP Protein, His (Fc)-Avi-tagged | +Inquiry |
ARL2BP-437R | Recombinant Rat ARL2BP Protein, His (Fc)-Avi-tagged | +Inquiry |
ARL2BP-1929M | Recombinant Mouse ARL2BP Protein | +Inquiry |
◆ Lysates | ||
ARL2BP-8715HCL | Recombinant Human ARL2BP 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionYes, genetic variations in the ARL2BP gene have been reported. For example, single nucleotide polymorphisms (SNPs) in the ARL2BP gene have been identified in some population studies. However, the functional consequences of these variants remain to be fully understood.
While the exact role of ARL2BP in human diseases is not well-established, there is emerging evidence suggesting its involvement in certain pathologies. For example, ARL2BP dysregulation has been observed in some cancer types, indicating its potential significance in tumorigenesis.
Yes, ARL2BP has been found to interact with additional proteins. For example, it can bind to BART (beta-amyloid precursor protein (APP)-binding protein), which is involved in the regulation of APP processing and Alzheimer's disease.
Currently, there is limited research on targeting ARL2BP for therapeutic purposes. However, further exploration into its functional roles and potential disease associations may reveal its suitability as a therapeutic target in the future.
Yes, ARL2BP can undergo post-translational modifications, including phosphorylation and ubiquitination. These modifications may regulate its stability, subcellular localization, or interaction with other proteins.
ARL2BP deficiency has been associated with certain cellular dysfunctions. Studies have suggested that decreased levels of ARL2BP can lead to impaired mitochondrial fusion and fission dynamics, as well as disruptions in Golgi morphology and protein trafficking.
ARL2BP is mainly localized to the cytoplasm but can also be found associated with specific cellular membranes, including the Golgi apparatus and the endoplasmic reticulum (ER).
Customer Reviews (8)
Write a reviewResearchers can confidently rely on its capabilities to generate precise and significant results, enhancing the understanding of protein function and dynamics.
It has demonstrated exceptional effectiveness in WB experiments, showcasing its reliability and precision in detecting and quantifying specific targets.
With ARL2BP protein, researchers can visualize protein complexes and their interactions with remarkable clarity, unraveling important insights into their functional mechanisms.
Its exceptional purity and stability make it an ideal choice for a wide range of applications, ensuring reliable and reproducible results.
Its unique characteristics contribute to obtaining clear and detailed structural information, allowing researchers to gain insights into protein interactions and conformational changes.
ARL2BP protein has proven to be instrumental in protein electron microscopy structure analysis.
This protein demonstrates exceptional performance in ELISA, delivering accurate and reliable results in the detection and quantification of specific antigens.
ARL2BP protein is highly recommended for scientific research applications, especially in ELISA assays and protein electron microscopy structure analysis.
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