Recombinant Human ADRM1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ADRM1-664H
• Product Overview: ADRM1 MS Standard C13 and N15-labeled recombinant protein (NP_008933) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 42.15 kDa
• AA Sequence: MTTSGALFPSLVPGSRGASNKYLVE FRAGKMSLKGTTVTPDKRKGLVYIQ QTDDSLIHFCWKDRTSGNVEDDLII FPDDCEFKRVPQCPSGRVYVLKFKA GSKRLFFWMQEPKTDQDEEHCRKVN EYLNNPPMPGALGASGSSGHELSAL GGEGGLQSLLGNMSHSQLMQLIGPA GLGGLGGLGALTGPGLASLLGSSGP PGSSSSSSSRSQSAAVTPSSTTSST RATPAPSAPAAASATSPSPAPSSGN GASTAASPTQPIQLSDLQSILATMN VPAGPAGGQQVDLASVLTPEIMAPI LANADVQERLLPYLPSGESLPQTAD EIQNTLTSPQFQQALGMFSAALASG QLGPLMCQFGLPAEAVEAANKGDVE AFAKAMQNNAKPEQKEGDTKDKKDE EEDMSLDTRTRPLEQKLISEEDLAA NDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ADRM1 adhesion regulating molecule 1 [ Homo sapiens (human) ]
• Official Symbol: ADRM1
• Synonyms: ADRM1; adhesion regulating molecule 1; proteasomal ubiquitin receptor ADRM1; ARM1; GP110; Rpn13; ARM-1; hRpn13; rpn13 homolog; M(r) 110,000 surface antigen; adhesion-regulating molecule 1; regulatory particle non-ATPase 13; 110 kDa cell membrane glycoprotein; proteasome regulatory particle non-ATPase 13; MGC29536
• Gene ID: 11047
• mRNA Refseq: NM_007002
• Protein Refseq: NP_008933
• MIM: 610650
• UniProt ID: Q16186

Reviews

09/16/2017

Exploring protein-protein interactions involved in viral infections.

03/09/2017

Detecting protein-protein interactions in multiprotein complexes.

01/28/2017

Understanding protein-protein interaction networks in chromatin remodeling.

Q&As

How is the expression level of ADRM1 protein regulated under normal physiological conditions?

The expression level of ADRM1 protein is regulated at the transcriptional and post-transcriptional levels by various cellular factors.

Are there any known post-translational modifications of ADRM1 protein and how do they affect its function?

Post-translational modifications, including phosphorylation and ubiquitination, have been identified on ADRM1 protein, which can modulate its stability and function.

What are the specific cellular processes or pathways in which ADRM1 protein is involved?

ADRM1 protein is primarily involved in the regulation of protein degradation through the ubiquitin-proteasome system.

What are the downstream targets or substrates of ADRM1 protein, and what are the consequences of their interaction?

ADRM1 protein interacts with ubiquitinated proteins, serving as a receptor to deliver them to the proteasome for degradation.

Are there any pharmacological agents or small molecules that can modulate the activity or expression of ADRM1 protein?

Some pharmacological agents, such as proteasome inhibitors, can affect the activity of ADRM1 protein indirectly by modulating the overall proteasome function. However, specific small molecules targeting ADRM1 directly are currently under investigation.

How does ADRM1 protein contribute to the development or progression of specific diseases or disorders?

Dysregulation of ADRM1 protein has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.

Are there any genetic or epigenetic factors that influence the expression or activity of ADRM1 protein?

Genetic and epigenetic factors can influence the expression and activity of ADRM1 protein, although specific regulatory mechanisms are still being elucidated.

What experimental techniques have been used to study the function of ADRM1 protein?

Various experimental techniques, such as protein-protein interaction assays, immunoprecipitation, and mass spectrometry, have been used to study the function of ADRM1 protein.

Can ADRM1 protein be localized to specific cellular compartments or structures?

ADRM1 protein is mainly localized to the cytoplasm and is associated with the 26S proteasome.

Can ADRM1 protein interact with other proteins or participate in protein complexes?

Yes, ADRM1 protein can interact with other proteins and participate in protein complexes involved in protein degradation processes.