Recombinant Human AFF3, His-tagged

• Cat.No.: AFF3-3232H
• Product Overview: AF4/FMR2 family member 3 (AFF3), partial

Specification

• Description: This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
• Source: E. Coli or Yeast
• Species: Human
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 1251
• Purity: >90%
• Notes: Small volumes of AFF3 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: AFF3 AF4/FMR2 family, member 3 [ Homo sapiens ]
• Official Symbol: AFF3
• Synonyms: AFF3; AF4/FMR2 family, member 3; LAF4, lymphoid nuclear protein related to AF4; AF4/FMR2 family member 3; MLLT2 like; protein LAF-4; MLLT2-related protein; lymphoid nuclear protein 4; lymphoid nuclear protein related to AF4; LAF4; MLLT2-like
• Gene ID: 3899
• mRNA Refseq: NM_001025108
• Protein Refseq: NP_001020279
• MIM: 601464
• UniProt ID: P51826
• Chromosome Location: 2q11.2-q12
• Function: DNA binding; double-stranded DNA binding

Reviews

11/01/2021

Elucidating protein-protein interactions in chromatin modifications for gene regulation.

05/09/2019

Exploring protein-protein interactions in epigenetic regulation for cellular memory.

04/04/2019

Unraveling protein-protein interactions in DNA replication for genome duplication.

Q&As

What experimental techniques or assays have been used to study the functional significance of AFF3 protein, such as chromatin immunoprecipitation, RNA-seq, or gene knockdown approaches?

Various experimental techniques or assays, such as chromatin immunoprecipitation, RNA-seq, or gene knockdown approaches, have been used to study the functional significance of AFF3 protein.

How is the expression of AFF3 protein regulated, and what factors or signaling pathways control its expression?

The expression of AFF3 protein is regulated by specific factors and signaling pathways.

How does dysregulation or dysfunction of AFF3 protein affect transcriptional regulation, gene expression networks, or disease development?

Dysregulation or dysfunction of AFF3 protein can affect transcriptional regulation, perturb gene expression networks, and contribute to disease development.

Can AFF3 protein be targeted or manipulated to modulate gene expression or disease phenotypes, and what are the potential implications for therapeutic interventions?

AFF3 protein holds potential as a target for modulating gene expression or disease phenotypes, and further research is needed to explore its implications for therapeutic interventions.

Does AFF3 protein interact with specific molecules or participate in protein complexes, and what are the functional implications of these interactions?

AFF3 protein may interact with specific molecules or participate in protein complexes, which have functional implications in cellular processes.

How does AFF3 protein contribute to cellular processes such as development, differentiation, or disease progression, and what are the underlying molecular mechanisms?

AFF3 protein contributes to cellular processes such as development, differentiation, or disease progression, and the underlying molecular mechanisms are currently being investigated.

What is the role of AFF3 protein in gene transcription or chromatin remodeling, and how can its function be investigated experimentally?

AFF3 protein plays a role in gene transcription or chromatin remodeling, and its function can be investigated using techniques like chromatin immunoprecipitation or gene expression analysis.

Are there any genetic variations or mutations in the gene encoding AFF3 protein that impact its expression or function, and what are the implications for cellular processes or disease susceptibility?

Genetic variations or mutations in the gene encoding AFF3 protein may impact its expression or function, influencing cellular processes or disease susceptibility.

What is the subcellular localization of AFF3 protein, and how can it be experimentally determined?

The subcellular localization of AFF3 protein can be experimentally determined using techniques such as immunofluorescence microscopy or subcellular fractionation.

Are there any known post-translational modifications or regulatory mechanisms that modulate the activity or stability of AFF3 protein?

Post-translational modifications and regulatory mechanisms may modulate the activity or stability of AFF3 protein.