Recombinant Human AGA protein, His-SUMO-tagged
Cat.No. : | AGA-2492H |
Product Overview : | Recombinant Human AGA protein(P20933)(24-205aa), fused to N-terminal His tag and SUMO tag, was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | His-SUMO |
Form : | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Molecular Mass : | 35.6 kDa |
Protein length : | 24-205aa |
AA Sequence : | SSPLPLVVNTWPFKNATEAAWRALA SGGSALDAVESGCAMCEREQCDGSV GFGGSPDELGETTLDAMIMDGTTMD VGAVGDLRRIKNAIGVARKVLEHTT HTLLVGESATTFAQSMGFINEDLST TASQALHSDWLARNCQPNYWRNVIP DPSKYCGPYKPPGILKQDIPIHKET EDDRGHD |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Reconstitution : | Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. |
Gene Name : | AGA aspartylglucosaminidase [ Homo sapiens ] |
Official Symbol : | AGA |
Synonyms : | AGA; aspartylglucosaminidase; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; ASRG; glycosylasparaginase; aspartylglucosylamine deaspartylase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase; GA; AGU; |
Gene ID : | 175 |
mRNA Refseq : | NM_000027 |
Protein Refseq : | NP_000018 |
MIM : | 613228 |
UniProt ID : | P20933 |
Products Types
◆ Recombinant Protein | ||
AGA-33C | Recombinant Cynomolgus Monkey AGA Protein, His (Fc)-Avi-tagged | +Inquiry |
Aga-550M | Recombinant Mouse Aga Protein, His-tagged | +Inquiry |
AGA-310H | Recombinant Human AGA Protein (206-346 aa), His-SUMO-tagged | +Inquiry |
AGA-211R | Recombinant Rat AGA Protein, His (Fc)-Avi-tagged | +Inquiry |
AGA-549H | Recombinant Human AGA Protein, His-tagged | +Inquiry |
◆ Lysates | ||
AGA-784HCL | Recombinant Human AGA cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionThe AGA protein is found in lysosomes, which are cell organelles involved in breaking down cellular waste.
Researchers used the PhosphoSitePlus tool and molecular dynamics simulations to analyze AGA protein phosphorylation.
Research investigates how AGA protein’s specificity for aspartylglucosamine residues influences substrate interactions.
AGA protein’s role contributes to maintaining lysosomal homeostasis and overall cellular health.
Deficiency of the AGA protein leads to Aspartylglucosaminuria, a rare genetic disorder characterized by the buildup of glycoproteins in the body.
The C163S mutant AGA protein exhibited increased hydrogen bonds and greater compactness compared to the wild type.
Yes, AGA protein’s activity might play a role in maintaining optimal lysosomal pH for enzymatic activity.
AGA protein’s role may include participating in lysosomal enzyme trafficking to enhance degradation processes.
Phosphorylated AGA forms (Y178-p, T215-p, T324-p) showed increased intramolecular hydrogen bonds and greater compactness.
Yes, AGA protein’s function impacts lysosomal enzyme activity and contributes to efficient degradation.
The AGA protein catalyzes the hydrolysis of N-linked glycoproteins, breaking them down into smaller components.
The AGA protein plays a role in the metabolism of glycoproteins.
Yes, AGA protein’s activity can be influenced by cellular conditions and the presence of its substrates.
Research aims to uncover how AGA protein’s function mitigates cellular responses to glycoprotein accumulation.
Yes, AGA protein’s role directly influences glycoprotein metabolism and turnover within cells.
Yes, AGA protein’s involvement can extend to lysosomal exocytosis and the release of lysosomal contents.
Research investigates AGA protein’s role in lysosomal storage disorders, aiding in understanding disease mechanisms.
In AGU, insufficient AGA activity leads to the buildup of glycoproteins, causing chronic neurodegeneration.
AGA protein’s function could impact cellular responses to lysosomal stressors and maintain lysosomal function.
Yes, AGA protein’s malfunction can lead to lysosomal storage disorders, disrupting glycoprotein degradation.
Customer Reviews (5)
Write a reviewThe product’s adaptability to various buffers contributed to its stable and consistent performance.
The consistent performance of the product simplified data interpretation.
Our research was fortified by the product’s consistent behavior, fostering robust results.
The high-quality Protein AGA enabled precise quantification of target proteins.
Our assays showed a significant increase in enzyme activity using Ag5.
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