Recombinant Human AGER, His-tagged
Cat.No. : | AGER-3648H |
Product Overview : | Total 339 AA. MW: 36.5 kDa. N-Terminal His-tag 14 AA (highlighted). |
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Cat. No. : | AGER-3648H |
Description : | RAGE, the Receptor for Advanced Glycation Endproducts is a 35kD transmembrane receptor of the immunoglobulin super family which was first characterized in 1992 by Neeper et al. It is also called AGER. |
Source : | E. coli |
Species : | Human |
Form : | Filtered (0.4 um) and lyophilized in 0.5 mg/ml in 0.03 M Acetate buffer, pH 4. |
Research topic : | Diabetology - Other Relevant Products, Neural tissue damage markers, Renal disease. |
Purity : | >95% |
Reconstitution : | Add 0.1M Acetate buffer pH4 to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10ug/ml. In higher concentrations the solubility of this antigen is limited. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
Applications : | Western blotting |
Quality Control Test : | BCA to determine quantity of the protein; SDS PAGE to determine purity of the protein |
Sequences of amino acids : | MRGSHHHHHH GMASAQNITA RIGEPLVLKC KGAPKKPPQR LEWKLNTGRT EAWKVLSPQG GGPWDSVARV LPNGSLFLPA VGIQDEGIFR CQAMNRNGKE TKSNYRVRVY QIPGKPEIVD SASELTAGVP NKVGTCVSEG SYPAGTLSWH LDGKPLVPNE KGVSVKEQTR RHPETGLFTL QSELMVTPAR GGDPRPTFSC SFSPGLPRHR ALRTAPIQPR VWEPVPLEEV QLVVEPEGGA VAPGGTVTLT CEVPAQPSPQ IHWMKDGVPL PLPPSPVLIL PEIGPQDQGT YSCVATHSSH GPQESRAVSI SIIEPGEEGP TAGEGFDKVR EAEDSPQHM |
Storage : | Store lyophilized protein at -20°C. Lyophilized protein remains stable until the expiry date when stored at -20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C. |
Gene Name : | AGER advanced glycosylation end product-specific receptor [ Homo sapiens ] |
Official Symbol : | AGER |
Synonyms : | AGER; advanced glycosylation end product-specific receptor; RAGE; MGC22357; OTTHUMP00000029155; OTTHUMP00000029156; OTTHUMP00000029157; OTTHUMP00000029158; OTTHUMP00000174885; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products; RAGE isoform delta; RAGE isoform NtRAGE-delta; RAGE isoform sRAGE-delta; receptor for advanced glycosylation end-products |
Gene ID : | 177 |
mRNA Refseq : | NM_001136 |
Protein Refseq : | NP_001127 |
MIM : | 600201 |
Uniprot ID : | Q15109 |
Chromosome Location : | 6p21.3 |
Function : | S100 alpha binding; advanced glycation end-product receptor activity; protein binding; receptor activity; transmembrane receptor activity |
Products Types
◆ Recombinant Protein | ||
AGER-3137H | Active Recombinant Human AGER protein(Met1-Ala344), hFc-tagged | +Inquiry |
Ager-3304M | Recombinant Mouse Ager protein(Met1-Ala342), His-tagged | +Inquiry |
Ager-712M | Recombinant Mouse Ager Protein, His-tagged | +Inquiry |
AGER-1061H | Recombinant Human AGER Protein (Met1-Ala342), HlgG1 Fc-tagged | +Inquiry |
Ager-3M | Recombinant Mouse Ager Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
AGER-2215MCL | Recombinant Mouse AGER cell lysate | +Inquiry |
AGER-2546HCL | Recombinant Human RAGE 293 Cell Lysate | +Inquiry |
AGER-1480HCL | Recombinant Human AGER cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionAGER is involved in bone metabolism and might influence osteoporosis and bone diseases.
AGER levels might serve as biomarkers for certain diseases, including diabetes.
AGER binds AGEs, initiating signaling cascades linked to inflammation, oxidative stress, and tissue damage.
AGER contributes to skin aging through oxidative stress and collagen damage.
AGER stands for "Advanced Glycosylation End-Product Specific Receptor," a cell surface receptor.
Yes, AGER activation contributes to inflammation and immune responses.
AGER activation can impair wound healing through inflammation and oxidative stress.
AGER contributes to neuroinflammation and might play a role in neurodegeneration.
AGER contributes to diabetic nephropathy and kidney dysfunction.
AGER binds to AGEs, initiating cellular signaling pathways linked to inflammation and oxidative stress.
AGER is implicated in lung diseases and inflammation, such as chronic obstructive pulmonary disease.
Researchers explore compounds that modulate AGER to mitigate its effects.
AGER contributes to diabetic complications by promoting inflammation and tissue damage.
AGER is studied for its implications in aging, diabetes, and various age-related diseases.
AGER plays a role in mediating cellular responses to advanced glycation end products (AGEs).
Consuming a low-AGE diet may help reduce AGER activation and its negative effects.
AGER activation affects immune cell functions and influences immune responses.
AGER activation is linked to cardiovascular diseases, including atherosclerosis.
Yes, besides AGEs, AGER interacts with other ligands like HMGB1 and β-amyloid.
Yes, ongoing research aims to uncover new roles and therapeutic targets related to AGER.
Customer Reviews (5)
Write a reviewIt's quality was evident in consistent results across replicates.
Protein consistently upregulated the expression of tissue-specific markers.
Gel electrophoresis bands displayed distinct separation, showcasing the product’s purity.
It’s consistent outcomes supported reliable statistical analysis.
Consistency and Compatibility Consistency in the product’s performance bolstered the credibility of our research findings.
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