Recombinant Human AGER, His-tagged

• Cat.No.: AGER-917H
• Product Overview: Recombinant Human sRAGE encoding the mature Human sRAGE (Ala23-AlaP342) with 6 His tag on the N-Terminus was expressed inE. Coli.This protein was purified by Ni-NTA column. MW = 39.0 KD.

Specification

• Cat. No.: AGER -917H
• Description: RAGE, the receptor for advanced glycation endproducts is a transmembrane receptor of the immunoglobulin super family which was first characterized in 1992 by Neeper et al. Its name comes from its ability to bind advanced glycation endproducts (AGE), a heterogeneous group of non-enzymatically altered proteins. Besides AGEs, RAGE is also able to bind other ligands and is thus often referred to as a pattern recognition receptor.
• Source: Escherichia Coli.
• Amino Acid Sequence: Human sRAGE (Ala23-AlaP342). 23AQNITARI GEPLVLKCKG APKKPPQRLE WKLNTGRTEAWKVLSPQGGG PWDSVARVLP NGSLFLPAVG IQDEGIFRCQ AMNRNGKETK SNYRVRVYQI PGKPEIVDSA SELTAGVPNK VGTCVSEGSY PAGTLSWHLD GKPLVPNEKG VSVKEQTRRHPETGLFTLQS ELMVTPARGG DPRPTFSCSF SPGLPRHRAL RTAPIQPRVW EPVPLEEVQL VVEPEGGAVA PGGTVTLTCE VPAQPSPQIH WMKDGVPLPL PPSPVLILPE IGPQDQGTYS CVATHSSHGP QESRAVSISI IEPGEEGPTA GSVGGSGLGTLA 342.
• Application: Cell biology.
• Purity: >95% in SDS gel.
• Formulation: Lyophilized 50 μg Human sRAGE in 50 μl of TBS ( 20 mM Tris, 50mM NaCl,pH8.0 ). Carry free.
• Reconstitution: Add 500 μl deionized water to the vial to prepare a working stock solution at 200 μg/mL . Allow to set at least 30 minutes at 4° C, mix well.
• Storage: Store lyophilized protein at -20 °C or -70 °C. Lyophilized protein is stable for up to 6 months from date of receipt at - 20 °C to -70 °C. Upon reconstitution, this protein can be stored at -20 °C for a few weeks or at -70 °C in a manual defrost freezer for long term storage (six months). Aliquot reconstituted protein to avoid repeated freezing / thawing cycles.

Gene Information

• Gene Name: AGER advanced glycosylation end product-specific receptor [ Homo sapiens ]
• Synonyms: AGER; advanced glycosylation end product-specific receptor; RAGE; MGC22357; receptor for advanced glycosylation end-products; Receptor for advanced glycosylation end products; MGC22357; OTTHUMP00000029155; OTTHUMP00000029156; advanced glycosylation end product-specific receptor
• Gene ID: 177
• mRNA Refseq: NM_001136
• Protein Refseq: NP_001127
• MIM: 600214
• UniProt ID: Q15109
• Chromosome Location: 6p21.3
• Function: advanced glycation end-product receptor activity; protein binding; transmembrane receptor activity

Reviews

02/26/2022

It's quality was evident in consistent results across replicates.

08/13/2021

 Protein consistently upregulated the expression of tissue-specific markers.

01/20/2020

 Gel electrophoresis bands displayed distinct separation, showcasing the product’s purity.

06/22/2019

It’s consistent outcomes supported reliable statistical analysis.

01/11/2017

Consistency and Compatibility Consistency in the product’s performance bolstered the credibility of our research findings.

Q&As

How does AGER affect bone health?

AGER is involved in bone metabolism and might influence osteoporosis and bone diseases.

Are there diagnostic applications for AGER?

AGER levels might serve as biomarkers for certain diseases, including diabetes.

How does AGER interact with AGEs?

AGER binds AGEs, initiating signaling cascades linked to inflammation, oxidative stress, and tissue damage.

How is AGER implicated in skin aging?

AGER contributes to skin aging through oxidative stress and collagen damage.

What is the AGER protein?

AGER stands for "Advanced Glycosylation End-Product Specific Receptor," a cell surface receptor.

Can the AGER protein impact inflammation?

Yes, AGER activation contributes to inflammation and immune responses.

How does AGER impact wound healing?

AGER activation can impair wound healing through inflammation and oxidative stress.

How does AGER influence neurodegenerative diseases?

AGER contributes to neuroinflammation and might play a role in neurodegeneration.

Can AGER influence kidney function?

AGER contributes to diabetic nephropathy and kidney dysfunction.

How does the AGER protein interact with AGEs?

AGER binds to AGEs, initiating cellular signaling pathways linked to inflammation and oxidative stress.

Can AGER influence lung health?

AGER is implicated in lung diseases and inflammation, such as chronic obstructive pulmonary disease.

Are there therapeutic strategies targeting AGER?

Researchers explore compounds that modulate AGER to mitigate its effects.

How is AGER involved in diabetic complications?

AGER contributes to diabetic complications by promoting inflammation and tissue damage.

How is the AGER protein involved in research?

AGER is studied for its implications in aging, diabetes, and various age-related diseases.

What is the function of the AGER protein?

AGER plays a role in mediating cellular responses to advanced glycation end products (AGEs).

Are there dietary interventions for AGER-related effects?

Consuming a low-AGE diet may help reduce AGER activation and its negative effects.

Can AGER impact immune responses?

AGER activation affects immune cell functions and influences immune responses.

Does AGER affect cardiovascular health?

AGER activation is linked to cardiovascular diseases, including atherosclerosis.

Are there other ligands for the AGER protein?

Yes, besides AGEs, AGER interacts with other ligands like HMGB1 and β-amyloid.

Is AGER research ongoing?

Yes, ongoing research aims to uncover new roles and therapeutic targets related to AGER.