Recombinant Human AGRP Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | AGRP-5468H |
Product Overview : | AGRP MS Standard C13 and N15-labeled recombinant protein (NP_001129) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
- Download
Description : | This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 14.4 kDa |
AA Sequence : | MLTAAVLSCALLLALPATRGAQMGL APMEGIRRPDQALLPELPGLGLRAP LKKTTAEQAEEDLLQEAQALAEVLD LQDREPRSSRRCVRLHESCLGQQVP CCDPCATCYCRFFNAFCYCRKLGTA MNPCSRTTRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | AGRP agouti related neuropeptide [ Homo sapiens (human) ] |
Official Symbol : | AGRP |
Synonyms : | AGRP; agouti related protein homolog (mouse); agouti (mouse) related protein; agouti-related protein; Agrt; ART; ASIP2; AGRT; |
Gene ID : | 181 |
mRNA Refseq : | NM_001138 |
Protein Refseq : | NP_001129 |
MIM : | 602311 |
UniProt ID : | O00253 |
Products Types
◆ Recombinant Protein | ||
Agrp-553M | Recombinant Mouse Agrp Protein, MYC/DDK-tagged | +Inquiry |
AGRP-94H | Recombinant Human AGRP Protein, His-tagged | +Inquiry |
AGRP-191H | Recombinant Human AGRP protein(Met1-Thr132), His-tagged | +Inquiry |
AGRP-3246H | Recombinant Human AGRP protein(Ser85-Thr132), hFc-tagged | +Inquiry |
AGRP-535H | Recombinant Human AGRP Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
AGRP-2471HCL | Recombinant Human AGRP cell lysate | +Inquiry |
AGRP-1142MCL | Recombinant Mouse AGRP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (10)
Ask a questionAGRP and the melanocortin system are potential targets for developing anti-obesity therapies, and research is ongoing to develop selective agonists or antagonists to modulate AGRP signaling.
AGRP is also implicated in the modulation of autonomic functions, such as blood pressure regulation and cardiovascular control.
AGRP inhibits the signaling of melanocortin receptors, leading to reduced cAMP production and affecting intracellular pathways involved in appetite and energy regulation.
AGRP acts as a key neuropeptide in the hypothalamus, integrating signals from peripheral tissues to regulate energy homeostasis, appetite, and body weight.
AGRP functions as an antagonist to melanocortin receptors, counteracting the effects of α-melanocyte-stimulating hormone (α-MSH), which promotes satiety and energy expenditure.
Yes, AGRP can interact with other neuropeptides, such as neuropeptide Y (NPY), and together they influence the central regulation of appetite and energy balance.
Dysregulation of AGRP expression or activity has been suggested to contribute to the development of certain eating disorders, such as binge eating disorder or hyperphagia.
While AGRP itself is not typically used as a diagnostic marker, studying its expression levels or genetic variations may provide insights into the risk and development of metabolic disorders.
AGRP acts on the melanocortin receptors in the brain, inhibiting their activation and resulting in an increase in appetite and a decrease in energy expenditure.
AGRP levels may have potential as a biomarker for monitoring the response to weight loss interventions, but further research is needed to establish its clinical utility.
Customer Reviews (5)
Write a reviewThis company offers a wide range of recombinant proteins at competitive prices.
The pricing structure for their proteins is transparent and reasonable.
The customer support team was extremely helpful and responsive, providing detailed information about the products.
We are exceedingly satisfied with the quality of this protein.
The exceptional quality of the proteins makes it a great value for the cost.
Ask a Question for All AGRP Products
Required fields are marked with *
My Review for All AGRP Products
Required fields are marked with *
Inquiry Basket