Recombinant Human AGXT Protein (Met1-Leu392), N-His-tagged
Cat.No. : | AGXT-0645H |
Product Overview : | Recombinant human AGXT (Met1-Leu392) was fused with the N-His tag and was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | N-His |
Form : | Lyophilized powder/frozen liquid |
Molecular Mass : | 45.32 kDa |
Protein Length : | Met1-Leu392 |
Purity : | >90% as determined by SDS-PAGE |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | 0.01M PBS, pH 7.4, 0.02% NLS |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | AGXT alanine-glyoxylate aminotransferase [ Homo sapiens (human) ] |
Official Symbol : | AGXT |
Synonyms : | AGXT; alanine-glyoxylate aminotransferase; SPAT; serine--pyruvate aminotransferase; AGT; AGT1; AGXT1; glycolicaciduria; L alanine: glyoxylate aminotransferase 1; oxalosis I; PH1; primary hyperoxaluria type 1; serine:pyruvate aminotransferase; SPT; serine-pyruvate aminotransferase; alanine--glyoxylate aminotransferase; L-alanine: glyoxylate aminotransferase 1; hepatic peroxisomal alanine:glyoxylate aminotransferase; TLH6; |
Gene ID : | 189 |
mRNA Refseq : | NM_000030 |
Protein Refseq : | NP_000021 |
MIM : | 604285 |
UniProt ID : | P21549 |
Products Types
◆ Recombinant Protein | ||
Agxt-504M | Recombinant Mouse Agxt Protein, His-tagged | +Inquiry |
AGXT-225R | Recombinant Rat AGXT Protein, His (Fc)-Avi-tagged | +Inquiry |
AGXT-314M | Recombinant Mouse AGXT Protein (25-414 aa), His-SUMO-tagged | +Inquiry |
Agxt-505R | Recombinant Rat Agxt Protein, His-tagged | +Inquiry |
AGXT-1322M | Recombinant Mouse AGXT Protein (25-414 aa), His-tagged | +Inquiry |
◆ Lysates | ||
AGXT-8967HCL | Recombinant Human AGXT 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAGXT contains a PLP-binding domain, characteristic of aminotransferases, which is critical for its enzymatic activity and substrate specificity.
Yes, mutations in the AGXT gene can cause primary hyperoxaluria type 1 (PH1), a rare autosomal recessive disorder characterized by the overproduction and accumulation of oxalate, resulting in severe kidney and urinary tract complications.
Targeting AGXT enzymatic activity may hold promise for developing therapies to prevent kidney stone formation in non-PH1 patients; however, further research is needed to validate this approach.
AGXT is primarily localized in the peroxisomes, a subcellular organelle responsible for various metabolic processes, including lipid metabolism and detoxification.
Epigenetic modifications, such as DNA methylation or histone acetylation, could potentially regulate AGXT gene expression and activity, affecting oxalate metabolism.
AGXT activity can be regulated by phosphorylation, allosteric modulation, and interaction with other proteins involved in peroxisomal metabolism.
AGXT plays a crucial role in the peroxisomal glyoxylate pathway, converting glyoxylate to glycine to prevent the accumulation of harmful oxalate, which can lead to kidney stone formation.
In PH1 patients, AGXT deficiency impairs the conversion of glyoxylate to glycine, leading to the accumulation of glyoxylate. Excessive glyoxylate is converted to oxalate, which can form kidney stones and cause tissue damage.
AGXT may participate in other cellular processes or metabolic pathways, and its broader functional roles warrant further exploration.
AGXT catalyzes the conversion of glyoxylate and L-alanine to glycine and pyruvate, utilizing PLP as a cofactor.
Customer Reviews (5)
Write a reviewThe customer service was fantastic—helpful, friendly, and made the ordering process a breeze!
The efficiency of this protein is outstanding. Saved me a lot of time!
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I'm so grateful for this protein – it's a game-changer for my studies!
I can confidently say that this product is worth every penny.
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