Recombinant Human AHCY Protein, Tag Free
Cat.No. : | AHCY-0569H |
Product Overview : | Recombinant human AHCY Protein without tag was expressed in E.coli. |
- Specification
- Gene Information
- Related Products
- Download
Source : | E. coli |
Species : | Human |
Tag : | Tag Free |
Form : | Lyophilized powder/frozen liquid |
Purity : | >90% as determined by SDS-PAGE |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | AHCY adenosylhomocysteinase [ Homo sapiens (human) ] |
Official Symbol : | AHCY |
Synonyms : | AHCY; adenosylhomocysteinase; S adenosylhomocysteine hydrolase; SAHH; adoHcyase; S-adenosylhomocysteine hydrolase; S-adenosyl-L-homocysteine hydrolase; |
Gene ID : | 191 |
mRNA Refseq : | NM_000687 |
Protein Refseq : | NP_000678 |
MIM : | 180960 |
UniProt ID : | P23526 |
Products Types
◆ Recombinant Protein | ||
AHCY-99H | Recombinant Human AHCY Protein, His-tagged | +Inquiry |
AHCY-35C | Recombinant Cynomolgus Monkey AHCY Protein, His (Fc)-Avi-tagged | +Inquiry |
AHCY-519H | Recombinant Human AHCY Protein, MYC/DDK-tagged | +Inquiry |
Ahcy-01M | Recombinant Mouse Ahcy Protein, His-tagged | +Inquiry |
Ahcy-1564M | Recombinant Mouse Ahcy Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
AHCY-8964HCL | Recombinant Human AHCY 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2151 | AHCY Inhibitor Screening Kit | +Inquiry |
Kit-2302 | Adenosylhomocysteinase (AHCY) Activity Fluorometric Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (10)
Ask a questionBy degrading SAH, AHCY ensures the availability of S-adenosylmethionine (SAM), a universal methyl donor essential for DNA, RNA, and protein methylation reactions.
Dysregulation of AHCY and altered methylation patterns have been linked to the development and progression of NAFLD and other liver pathologies.
AHCY employs a zinc-dependent mechanism to cleave the N-ribosidic bond of SAH, generating adenosine and homocysteine as products.
Targeting AHCY activity or SAM availability holds promise as a potential therapeutic strategy for conditions influenced by disrupted methylation.
Single nucleotide polymorphisms (SNPs) in the AHCY gene can affect enzyme activity and SAH levels, potentially influencing disease risk, including cardiovascular disorders and neurodegenerative diseases.
Homocysteine can be remethylated to methionine through the folate-dependent pathway or transsulfurated to cysteine via the transsulfuration pathway.
AHCY activity is intimately connected with folate-mediated one-carbon metabolism, affecting the availability of methyl groups for various methylation reactions.
AHCY expression can be modulated by transcriptional factors and epigenetic modifications, responding to changes in cellular methylation needs.
AHCY indirectly influences polyamine biosynthesis by providing the methyl groups required for polyamine synthesis.
AHCY possesses a TIM-barrel fold with an active site that houses the zinc ion critical for its hydrolytic activity.
Customer Reviews (5)
Write a reviewMy experiments have never been smoother since I started using this protein.
In our scientific pursuits, this lab protein has surpassed expectations, demonstrating exceptional quality and ease of use.
I highly recommend this protein to fellow researchers. It's a true gem!
We wholeheartedly endorse the lab protein product for its outstanding performance and its significant contribution to our research outcomes.
This protein is like a reliable teammate in the lab – always delivering excellent results.
Ask a Question for All AHCY Products
Required fields are marked with *
My Review for All AHCY Products
Required fields are marked with *
Inquiry Basket