Recombinant Human AHRR protein, His & GST-tagged
Cat.No. : | AHRR-1698H |
Product Overview : | Recombinant Human AHRR aa. (Met1~Pro182 (Accession # A9YTQ3)) fused with N-terminal His & GST tag was produced in E. coli cells. |
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Description : | The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
Source : | E. coli |
Species : | Human |
Tag : | His & GST |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 50.4kDa |
Protein length : | Met1~Pro182 (Accession # A9YTQ3) |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | >90% |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative. |
Reconstitution : | Reconstitute in sterile ddH2O. |
Isoelectric Point : | 8.8 |
Gene Name : | AHRR aryl-hydrocarbon receptor repressor [ Homo sapiens (human) ] |
Official Symbol : | AHRR |
Synonyms : | AHRR; aryl-hydrocarbon receptor repressor; AHH; AHHR; bHLHe77; aryl hydrocarbon receptor repressor; ahR repressor; aryl hydrocarbon hydroxylase regulator; class E basic helix-loop-helix protein 77; dioxin receptor repressor |
Gene ID : | 57491 |
mRNA Refseq : | NM_001242412.1 |
Protein Refseq : | NP_001229341.1 |
UniProt ID : | A9YTQ3 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionGenetic variations in AHRR can lead to altered protein function and influence individual susceptibility to diseases influenced by the AHR signaling pathway, such as cancer and immune-related disorders.
AHRR expression can influence an individual's sensitivity to environmental carcinogens and toxicants by modulating AHR activity and downstream gene expression.
AHRR expression levels can vary among tissues and cell types, depending on the local microenvironment, exposure to specific ligands, and tissue-specific transcriptional regulators.
AHRR contains domains that enable its interaction with AHR, such as bHLH (basic helix-loop-helix) and PAS (Per-Arnt-Sim) domains, facilitating the formation of inhibitory complexes with AHR.
AHRR acts as a negative regulator of the AHR signaling pathway, inhibiting AHR-mediated gene transcription in response to ligand activation.
AHRR competes with AHR for binding to the same target genes, effectively blocking AHR-mediated transcription and inhibiting the expression of AHR-responsive genes.
AHRR is implicated in modulating inflammatory responses and immune cell differentiation, affecting the balance between pro-inflammatory and anti-inflammatory signals.
AHRR expression can be induced by various environmental stimuli, such as exposure to AHR ligands and other stressors. Transcription factors and epigenetic modifications can regulate AHRR gene expression.
AHRR plays a crucial role in regulating the expression of genes involved in xenobiotic metabolism and detoxification, contributing to the body's defense against environmental toxins.
AHRR is involved in circadian rhythm regulation and contributes to metabolic homeostasis by influencing the expression of clock genes and metabolic regulators.
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