Recombinant Human AIMP2 293 Cell Lysate
Cat.No. : | AIMP2-8951HCL |
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Description : | Antigen standard for aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection. |
Source : | HEK 293 cells |
Species : | Human |
Components : | This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol). |
Size : | 0.1 mg |
Storage Instruction : | Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment. |
Applications : | ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane. |
Gene Name : | AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 [ Homo sapiens ] |
Official Symbol : | AIMP2 |
Synonyms : | AIMP2; aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; aminoacyl tRNA synthase complex-interacting multifunctional protein 2; JTV 1; JTV1; p38; PRO0992; protein JTV-1; ARS-interacting multi-functional protein 2; multisynthase complex auxiliary component p38; multisynthetase complex auxiliary component p38; P38; JTV-1; |
Gene ID : | 7965 |
mRNA Refseq : | NM_006303 |
Protein Refseq : | NP_006294 |
MIM : | 600859 |
UniProt ID : | Q13155 |
Chromosome Location : | 7p22.1 |
Pathway : | Cytosolic tRNA aminoacylation, organism-specific biosystem; Gene Expression, organism-specific biosystem; Keap1-Nrf2 Pathway, organism-specific biosystem; tRNA Aminoacylation, organism-specific biosystem; |
Function : | protein binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (8)
Ask a questionYes, mutations in AIMP2 have been associated with several human diseases. For example, a point mutation in the AIMP2 gene has been linked to Charcot-Marie-Tooth disease, a genetic disorder that affects the peripheral nerves and muscles. Additionally, a genetic variation in the promoter region of AIMP2 has been found to be associated with an increased risk of gastric cancer. Furthermore, altered AIMP2 expression levels have been observed in various other diseases, including inflammatory and autoimmune conditions, and neurodegenerative disorders.
AIMP2 is an essential component of the multi-enzyme complex called the aminoacyl-tRNA synthetase complex, which helps in the translation of genetic information from DNA into proteins. Specifically, AIMP2 functions as a subunit of the complex that connects aminoacyl-tRNA synthetases with translation factors to ensure the accurate incorporation of amino acids into proteins. AIMP2 also has additional functions in the regulation of protein synthesis, including the promotion of ribosomal biogenesis and activity.
Yes, AIMP2 has been implicated in the development and progression of various types of cancer. AIMP2 has been shown to promote cancer cell proliferation and invasion in several types of cancer, including lung, colon, and breast cancer.
There is evidence to suggest that AIMP2 may play a role in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. AIMP2 has been found to interact with proteins involved in neural function and survival, and its expression levels have been shown to be altered in the brains of patients with these diseases.
AIMP2 is expressed in most tissues and cell types, with particularly high levels found in the brain, liver, and muscle. AIMP2 expression levels can also be regulated by various factors such as stress, tissue injury, and inflammation.
Mutations in AIMP2 are rare, but they have been implicated in Charcot-Marie-Tooth disease (CMT) type 2Z, a progressive neurological disorder that affects the peripheral nerves. Additionally, AIMP2 has been proposed as a potential therapeutic target for cancer and autoimmune disorders.
Yes, AIMP2 is a potential target for therapeutic interventions in cancer, inflammation, and other diseases. For example, compounds that inhibit AIMP2 have been developed and tested in preclinical studies for their potential to treat various types of cancer. In addition, targeting AIMP2 may be a potential strategy for reducing inflammation in certain disease states. However, more research is needed to determine the efficacy and safety of AIMP2-targeted therapies.
There is some evidence to suggest that AIMP2 expression levels may be associated with cancer progression and patient outcomes, but more research is needed to determine its potential as a diagnostic or prognostic marker. In addition, AIMP2-targeted therapies are still in the early stages of development and may not be widely available.
Customer Reviews (3)
Write a reviewAIMP2 protein showcases an extraordinary level of quality, making it an optimal choice to meet my experimental demands.
To further enhance its value, the manufacturer offers unparalleled technical support.
The dedicated support team possesses a profound understanding of the intricacies associated with the AIMP2 protein, capable of addressing any challenges or queries I may encounter.
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