Recombinant Human AKIP1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | AKIP1-6193H |
Product Overview : | C11orf17 MS Standard C13 and N15-labeled recombinant protein (NP_065693) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 22.9 kDa |
AA Sequence : | MDNCLAAAALNGVDRRSLQRSARLA LEVLERAKRRAVDWHALERPKGCMG VLAREAPHLEKQPAAGPQRVLPGER EERPPTLSASFRTMAEFMDYTSSQC GKYYSSVPEEGGATHVYRYHRGESK LHMCLDIGNGQRKDRKKTSLGPGGS YQISEHAPEASQPAENISKDLYIEV YPGTYSVTVGSNDLTKKTHVVAVDS GQSVDLVFPVTRTRPLEQKLISEED LAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
SDS-PAGE: |
Gene Name : | AKIP1 A-kinase interacting protein 1 [ Homo sapiens (human) ] |
Official Symbol : | AKIP1 |
Synonyms : | AKIP1; A kinase (PRKA) interacting protein 1; C11orf17, chromosome 11 open reading frame 17; A-kinase-interacting protein 1; BCA3; koyt binding protein 1; koyt binding protein 2; koyt binding protein 3; proline-rich protein BCA3; breast cancer associated gene 3; C11orf17; |
Gene ID : | 56672 |
mRNA Refseq : | NM_020642 |
Protein Refseq : | NP_065693 |
MIM : | 609191 |
UniProt ID : | Q9NQ31 |
Products Types
◆ Recombinant Protein | ||
AKIP1-461H | Recombinant Human AKIP1 Protein, GST-tagged | +Inquiry |
AKIP1-432M | Recombinant Mouse AKIP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Akip1-1580M | Recombinant Mouse Akip1 Protein, Myc/DDK-tagged | +Inquiry |
AKIP1-1484M | Recombinant Mouse AKIP1 Protein | +Inquiry |
◆ Lysates | ||
AKIP1-8354HCL | Recombinant Human C11orf17 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionAKIP1 has been implicated in several signaling pathways. It has been reported to modulate the activity of the ERK1/2 (extracellular signal-regulated kinase 1/2) pathway, a major signaling cascade involved in cell proliferation and survival. When AKIP1 interacts with the oncogenic protein RAF1, it can enhance ERK1/2 signaling.
AKIP1 has been investigated as a potential biomarker in certain cancers. For example, increased AKIP1 expression has been observed in breast, prostate, and colorectal cancer tissues compared to normal tissues, suggesting its potential as a diagnostic or prognostic biomarker. However, further studies are needed to validate its utility as a biomarker and establish its clinical significance in disease diagnosis and management.
AKIP1 has been found to modulate transcriptional activity by interacting with transcription factors and co-regulators. It can associate with components of the basal transcriptional machinery and influence gene expression. AKIP1 has been shown to regulate the activity of NF-κB and modulate the transcription of target genes involved in inflammation and cancer.
Yes, post-translational modifications can impact AKIP1 function. Phosphorylation of AKIP1 by protein kinases such as PKA (protein kinase A) and MAPK (mitogen-activated protein kinase) can regulate its interaction with other proteins and affect its subcellular localization. Acetylation of AKIP1 by the acetyltransferase p300/CBP (CREB-binding protein) can enhance its stability and prevent proteasomal degradation.
Limited research suggests that AKIP1 may play a role in cell cycle regulation by influencing cyclin D1 expression and cyclin-dependent kinase activity. However, the exact mechanisms by which AKIP1 affects cell cycle progression and checkpoints are not yet well understood and require further investigation.
AKIP1 regulation is not fully understood, but it can be influenced by various factors. It is known that certain cellular signaling pathways, such as the PKA signaling pathway, can modulate AKIP1 expression and activity. Additionally, post-translational modifications, including phosphorylation, can impact AKIP1 function. Further investigation is required to unravel the complete mechanisms of AKIP1 regulation.
AKIP1 can be present in different cellular compartments depending on its interacting partners and cellular context. It has been found in the nucleus, cytoplasm, and mitochondria. AKIP1 localization is influenced by factors such as phosphorylation and protein-protein interactions.
Yes, AKIP1 has been explored as a potential therapeutic target in cancer treatment. Inhibiting AKIP1 expression or activity may help to suppress tumor growth, metastasis, and enhance the efficacy of existing anticancer therapies. However, the development of specific AKIP1-targeting drugs is still in the early stages and requires further research and validation.
Yes, AKIP1 has been found to localize to the mitochondria and play a role in mitochondrial function. It has been implicated in regulating mitochondrial protein import, maintaining mitochondrial membrane potential, and promoting mitochondrial oxidative phosphorylation. AKIP1 has also been associated with mitochondrial dynamics, particularly mitochondrial fission.
Yes, AKIP1 interacts with several proteins to carry out its functions. Some known protein partners of AKIP1 include the regulatory subunits of PKA, HDAC1 (histone deacetylase 1), p65 subunit of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), and STAT3 (signal transducer and activator of transcription 3), among others.
There is limited evidence suggesting that AKIP1 may have a role in DNA repair processes. It has been reported to interact with the DNA repair protein Ku70, which is involved in non-homologous end joining (NHEJ), a DNA repair pathway. AKIP1 overexpression in breast cancer cells has been shown to enhance the repair of radiation-induced DNA damage, possibly through its interaction with Ku70.
AKIP1 binds to the regulatory subunits of PKA and inhibits its activity. This interaction prevents the activation of PKA and influences downstream signaling pathways. AKIP1 may also participate in regulating the localization of PKA within the cell.
Yes, AKIP1 has been found to interact with several proteins. It has been reported to interact with the androgen receptor (AR), a transcription factor involved in male sexual development, and play a role in AR-mediated gene transcription. AKIP1 has also been shown to interact with the DNA repair protein Ku70, as mentioned earlier, and contribute to DNA repair processes. Additionally, AKIP1 has been found to interact with components of the TACC (Transforming Acidic Coiled-Coil) family of proteins, which are involved in spindle assembly and cell division.
The transcriptional regulation of AKIP1 is not well understood. However, several studies have identified potential transcription factors that can bind to the promoter region of the AKIP1 gene and modulate its expression. For example, the transcription factors Sp1 and Sp3 have been shown to interact with the AKIP1 promoter and activate its transcription. Additionally, the tumor suppressor p53 has been reported to bind to the AKIP1 promoter and negatively regulate its expression.
AKIP1 has been found to be involved in various aspects of cancer development and progression. Its overexpression has been observed in several types of tumors, and it promotes cell proliferation, migration, invasion, and resistance to cell death. It is considered a potential oncogene and a target for cancer therapy.
Yes, AKIP1 has orthologs in various species. Human AKIP1 shares high sequence similarity with AKIP1 proteins in other mammals, such as mice, rats, and dogs. Additionally, orthologs of AKIP1 have been identified in non-mammalian species, including chicken, zebrafish, and fruit fly. These orthologs likely perform similar functions to human AKIP1, although their exact roles may vary between species.
There have been limited studies investigating mutations in the AKIP1 gene. However, some studies have identified single nucleotide polymorphisms (SNPs) in the AKIP1 gene that may be associated with certain diseases and conditions. For example, a specific SNP in the AKIP1 gene has been found to be associated with an increased risk of developing schizophrenia in some populations. Further research is needed to fully understand the impact of these mutations and their role in disease.
While AKIP1 is not directly linked to any specific diseases, altered expression or dysregulation of AKIP1 has been observed in several cancers, including breast, prostate, colorectal, and lung cancer. Its overexpression in cancer cells has been associated with tumor progression, metastasis, and drug resistance. AKIP1 may serve as a potential therapeutic target in cancer treatment.
Mutations in the AKIP1 gene are relatively rare and have not been extensively studied. However, some studies have suggested potential associations between AKIP1 gene mutations and certain diseases, such as prostate cancer. Further research is needed to understand the significance of these mutations.
The utility of AKIP1 as a biomarker in cancer diagnosis or prognosis has not been extensively studied. However, some studies have suggested its potential as a prognostic marker in certain cancers, such as breast and lung cancer. Further research is needed to establish its clinical significance as a biomarker.
Customer Reviews (4)
Write a reviewThe AKIP1 protein exhibits an exceptional level of quality that perfectly aligns with my experimental requirements.
With the AKIP1 protein's excellent attributes, I am confident that it will not only meet but surpass my experimental needs, ensuring accurate and reliable results.
Its superior purity and consistent performance make it an ideal choice to fulfill my research objectives.
the manufacturer of the AKIP1 protein offers outstanding technical support, which adds to the value of this product.
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