Recombinant Human AKR1B15, His-tagged

• Cat.No.: AKR1B15-3267H
• Product Overview: Aldo-keto reductase family 1 member B15 (AKR1B15)

Specification

• Source: E. Coli or Yeast
• Species: Human
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 344
• Purity: >90%
• Notes: Small volumes of AKR1B15 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: AKR1B15 aldo-keto reductase family 1, member B15 [ Homo sapiens ]
• Official Symbol: AKR1B15
• Synonyms: AKR1B10L
• Gene ID: 441282
• mRNA Refseq: NM_001080538
• Protein Refseq: NP_001074007
• MIM: C9JRZ8
• UniProt ID: C9JRZ8
• Chromosome Location: 7q33
• Pathway: Disease, organism-specific biosystem; Diseases associated with visual transduction, organism-specific biosystem
• Function: oxidoreductase activity

Reviews

08/28/2022

AKR1B15 has similar activity to the native protein and is able to perform the expected biological functions.

05/30/2021

This protein is highly expressed and can efficiently synthesize a large number of target proteins in host cells.

09/30/2019

AKR1B15 was stable in solution and not easily aggregated or inactivated.

09/19/2019

Highly purified and was not doped with other proteins or impurities.

Q&As

Is there a link between AKR1B15 and cancer?

Ketose reductase is overexpressed in some cancer types, such as lung and breast cancer. There may be potential for ketose reductase as a cancer therapeutic target, although more research is still needed to determine its feasibility for clinical use.

Has the current study found that AKR1B15 is associated with human disease

While the exact role of AKR1B15 in disease is not well understood, altered expression or activity of AKR1B15 has been associated with certain types of cancers, such as hepatocellular carcinoma.

Where ARIB15 is found in the human body？

AKR1B15 refers to Aldo-keto reductase family 1 member B15, which is a protein encoded by the AKR1B15 gene. AKR1B15 belongs to the aldo-keto reductase (AKR) superfamily and is involved in the metabolism of various endogenous compounds and xenobiotics.

What are the organizational characteristics of AKR1B15?

It is primarily expressed in the liver, but can also be found in other tissues such as the kidney and lung.

What are the action mechanisms of AKR1B15 in the human body?

AKR1B15 is involved in the regulation of glucose metabolism in humans. It is capable of converting glucose to glucuronic acid and reducing glucuronic acid to glucose. This process is important for maintaining normal blood sugar levels.AKR1B15 also has antioxidant stress effects. It can protect cells from oxidative stress by scavenging free radicals and alleviating oxidative damage.

Is AKR1B15 similar in quality control structure to other proteins in the same family?

KR1B15 shares common structural features with other members of the AKR family, including a conserved NADPH-binding site and a catalytic domain responsible for its enzymatic activity.

Which cell signaling pathways does AKR1B15 protein participate in?

The AKR1B15 protein, a member of the aldo-keto reductase (AKR) family, has not been extensively studied, and its involvement in cell signaling pathways is currently not well-defined. As of my knowledge, there are no specific cell signaling pathways reported to involve AKR1B15. However, it's worth noting that other members of the AKR family, such as AKR1B1 and AKR1B10, have been implicated in various cellular processes and signaling pathways, including those related to glucose metabolism, lipid metabolism, inflammation, and oxidative stress. Further research is necessary to determine the exact signaling pathways associated with AKR1B15.

Whether inflammatory diseases is influenced by AKR1B15?

Ketose reductase may be involved in the regulation of some inflammatory processes. The researchers believe that this gene may be involved in the development of diseases such as inflammatory bowel disease.

In addition to glucose metabolism and oxidative stress, what are the other roles of AKR1B15?

There is a link between AKR1B15 and diabetes. The study found that this enzyme may be involved in metabolic disorders caused by hyperglycemia and is associated with the occurrence and development of diabetic complications such as retinopathy and neuropathy.In addition, AKR1B15 is also involved in the metabolism and detoxification of certain drugs. It is involved in the metabolism of several endogenous and exogenous compounds, including hormones, ketone bodies, and environmental toxins.

Whether AKR1B15 has substrate specificity？

KR1B15 has been shown to have broad substrate specificity, including the reduction of carbonyl compounds like steroids, prostaglandins, and xenobiotics.

Does AKR1B15 is associated with diabetes, and what?

There may be an association between ketose reductase and the development of diabetes mellitus. Studies have shown that ketose reductase is involved in the regulation of intracellular glucose metabolism and insulin secretion. Further studies may reveal the role of this gene in the pathogenesis of diabetes.