Recombinant Human ALDOB
Cat.No. : | ALDOB-26495TH |
Product Overview : | Recombinant fragment of Human ALDOB with an N terminal proprietary tag; Predicted MWt 34.76 kDa. |
- Specification
- Gene Information
- Related Products
- Download
Description : | Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related housekeeping genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. |
Protein length : | 83 amino acids |
Molecular Weight : | 34.760kDa inclusive of tags |
Source : | Wheat germ |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | DSQGKLFRNILKEKGIVVGIKLDQG GAPLAGTNKETTIQGLDGLSERCAQ YKKDGVDFGKWRAVLRIADQCPSSL AIQENANA |
Sequence Similarities : | Belongs to the class I fructose-bisphosphate aldolase family. |
Gene Name : | ALDOB aldolase B, fructose-bisphosphate [ Homo sapiens ] |
Official Symbol : | ALDOB |
Synonyms : | ALDOB; aldolase B, fructose-bisphosphate; fructose-bisphosphate aldolase B; |
Gene ID : | 229 |
mRNA Refseq : | NM_000035 |
Protein Refseq : | NP_000026 |
MIM : | 612724 |
Uniprot ID : | P05062 |
Chromosome Location : | 9q21.3-q22.2 |
Pathway : | FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Fructose and mannose metabolism, organism-specific biosystem; Fructose and mannose metabolism, conserved biosystem; Fructose catabolism, organism-specific biosystem; Gluconeogenesis, organism-specific biosystem; |
Function : | ATPase binding; cytoskeletal protein binding; fructose binding; fructose-bisphosphate aldolase activity; fructose-bisphosphate aldolase activity; |
Products Types
◆ Recombinant Protein | ||
ALDOB-1325R | Recombinant Rabbit ALDOB Protein (2-364 aa), His-tagged | +Inquiry |
ALDOB-326R | Recombinant Rabbit ALDOB Protein (2-364 aa), His-SUMO-tagged | +Inquiry |
Aldob-1596M | Recombinant Mouse Aldob Protein, Myc/DDK-tagged | +Inquiry |
ALDOB-0641H | Recombinant Human ALDOB Protein (Thr9-Tyr364), N-His-tagged | +Inquiry |
ALDOB-9718Z | Recombinant Zebrafish ALDOB | +Inquiry |
◆ Lysates | ||
ALDOB-8911HCL | Recombinant Human ALDOB 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionHereditary fructose intolerance is caused by a genetic mutation in the ALDOB gene, which leads to a deficiency or complete absence of the ALDOB protein. Without functioning ALDOB protein, the body is unable to properly metabolize fructose, leading to a build-up of toxic byproducts and causing the symptoms of HFI.
Yes, there are multiple mutations identified in the ALDOB gene that can cause hereditary fructose intolerance. These mutations can vary in their severity and impact on the function of the ALDOB protein.
Yes, mutations in the ALDOB gene can have other health implications. In some cases, mutations that cause a partial deficiency of the ALDOB protein may lead to a milder form of fructose intolerance or cause symptoms only when excessive amounts of fructose are consumed. Additionally, there is some evidence to suggest that ALDOB gene mutations may be associated with an increased risk of developing certain types of liver diseases. However, further research is needed to fully understand the potential implications.
Yes, prenatal testing is available for hereditary fructose intolerance. It involves analyzing fetal DNA obtained through procedures like chorionic villus sampling (CVS) or amniocentesis to identify mutations in the ALDOB gene. This allows for early detection of the condition, aiding in family planning and preparation for managing the condition after birth.
The ALDOB protein is primarily involved in fructose metabolism, but it also has other functions. It plays a role in gluconeogenesis, a process in which the liver produces glucose from non-carbohydrate sources. It is also involved in maintaining the balance of sugar molecules in the body and supporting normal liver function.
Hereditary fructose intolerance is typically diagnosed through a combination of clinical symptoms, biochemical testing, and genetic testing. Symptoms of the condition may include abdominal pain, nausea, vomiting, and low blood sugar levels. Biochemical testing involves measuring the levels of certain metabolites, such as fructose and its byproducts, in the blood or urine. Genetic testing can confirm the presence of specific mutations in the ALDOB gene.
Customer Reviews (3)
Write a reviewIt has been extensively used in protein-protein interaction studies, enzymatic assays, and structural analyses, showcasing its reliability and adaptability in diverse research areas.
With the ALDOB Protein, I have the confidence to generate critical insights and drive significant advancements in my field.
I am certain of obtaining reliable and reproducible results, enabling me to contribute to scientific progress and make new discoveries.
Ask a Question for All ALDOB Products
Required fields are marked with *
My Review for All ALDOB Products
Required fields are marked with *
Inquiry Basket