Recombinant Human ALKBH3 Protein, GST-tagged
Cat.No. : | ALKBH3-2538H |
Product Overview : | Human DEPC-1 full-length ORF ( AAH15155, 1 a.a. - 139 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 41.03 kDa |
AA Sequence : | MEPNPHWHPVLRTLKNRIEENTGHT FNSLLCNLYRNEKDSVDWHSDDEPS LGRCPIIASLSFGATRTFEMRKKPP PEENGDYTYVERVKIPLDHGTLLIM EGATQADWQHRVPKEYHSREPRVNL TFRTVYPDPRGAPW |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ALKBH3 alkB, alkylation repair homolog 3 (E. coli) [ Homo sapiens ] |
Official Symbol : | ALKBH3 |
Synonyms : | ALKBH3; alkB, alkylation repair homolog 3 (E. coli); alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; DEPC 1; prostate cancer antigen 1; prostate cancer antigen-1; alkylated DNA repair protein alkB homolog 3; ABH3; PCA1; DEPC1; DEPC-1; FLJ43614; MGC118790; MGC118792; MGC118793; |
Gene ID : | 221120 |
mRNA Refseq : | NM_139178 |
Protein Refseq : | NP_631917 |
MIM : | 610603 |
UniProt ID : | Q96Q83 |
Products Types
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ALKBH3-475M | Recombinant Mouse ALKBH3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ALKBH3-320H | Recombinant Human ALKBH3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ALKBH3-134R | Recombinant Rhesus Macaque ALKBH3 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ALKBH3-8901HCL | Recombinant Human ALKBH3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (17)
Ask a questionALKBH3 gene mutation is associated with colon and rectal cancer.
The stability of ALKBH3 recombinant protein is related to freezing temperature, pH value and ionic strength.
ALKBH3 is a DNA repair enzyme that repairs methyl groups along DNA strands.
No studies have shown that ALKBH3 mutations are associated with recurrent liver cancer.
At present, there is no clear study that ALKBH3 gene is related to drug metabolism.
ALKBH3 gene can be used as one of the molecular markers of liver cancer prognosis.
There is no clear evidence that ALKBH3 recombinant protein has immunomodulatory effects.
ALKBH3 gene polymorphism is associated with various cancers such as lung cancer, esophageal cancer and colon cancer.
Mutations in ALKBH3 may affect the function of DNA damage repair.
ALKBH3 recombinant protein should be stored in a -80℃ refrigerator to ensure stability.
ALKBH3 recombinant protein can help predict the therapeutic effect and prognosis of some cancers.
ALKBH3 has not been found to affect human metabolic capacity.
No studies have shown that ALKBH3 has an important effect on the immune system.
There are no clear dosage guidelines at present, and further research is needed to determine.
ALKBH3 mutation may affect the treatment response of liver cancer.
There is no strong evidence that the ALKBH3 gene variant can be used as an early warning indicator of cancer.
The recombinant ALKBH3 protein may be a potential target for the treatment of some cancers, but further research is needed to confirm it.
Customer Reviews (3)
Write a reviewStructure analysis by nuclear magnetic resonance (NMR), X-ray crystallography or electron microscopy showed that ALKBH3 was stable.
Prone to induce immune responses.
Stable under special conditions.
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