Recombinant Human ALOX15B
Cat.No. : | ALOX15B-26021TH |
Product Overview : | Recombinant fragment of Human 15 Lipoxygenase 2 with N terminal proprietary tag, 36.63kDa inclusive of tag. |
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Description : | This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. |
Protein length : | 100 amino acids |
Molecular Weight : | 36.630kDa inclusive of tags |
Source : | Wheat germ |
Tissue specificity : | Expressed in hair, prostate, lung and cornea. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | NANFYLQAGSAFAEMKIKGLLDRKG LWRSLNEMKRIFNFRRTPAAEHAFE HWQEDAFFASQFLNGLNPVLIRRCH YLPKNFPVTDAMVASVLGPGTSLQA |
Sequence Similarities : | Belongs to the lipoxygenase family.Contains 1 lipoxygenase domain.Contains 1 PLAT domain. |
Gene Name : | ALOX15B arachidonate 15-lipoxygenase, type B [ Homo sapiens ] |
Official Symbol : | ALOX15B |
Synonyms : | ALOX15B; arachidonate 15-lipoxygenase, type B; arachidonate 15 lipoxygenase, second type; arachidonate 15-lipoxygenase B; 15 LOX 2; |
Gene ID : | 247 |
mRNA Refseq : | NM_001039130 |
Protein Refseq : | NP_001034219 |
MIM : | 603697 |
Uniprot ID : | O15296 |
Chromosome Location : | 17p13.1 |
Pathway : | Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Eicosanoid Synthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Selenium Pathway, organism-specific biosystem; |
Function : | arachidonate 15-lipoxygenase activity; iron ion binding; lipoxygenase activity; metal ion binding; oxidoreductase activity; |
Products Types
◆ Recombinant Protein | ||
ALOX15B-1316H | Recombinant Human ALOX15B protein(Met1-Ile676), His&GST-tagged | +Inquiry |
ALOX15B-293R | Recombinant Rat ALOX15B Protein, His (Fc)-Avi-tagged | +Inquiry |
ALOX15B-40H | Recombinant Human ALOX15B Protein, His-tagged | +Inquiry |
ALOX15B-054H | Recombinant Human ALOX15B Protein, His-tagged | +Inquiry |
ALOX15B-3241H | Recombinant Human ALOX15B protein(Met1-Ile676) | +Inquiry |
◆ Lysates | ||
ALOX15B-001HCL | Recombinant Human ALOX15B cell lysate | +Inquiry |
ALOX15B-002HCL | Recombinant Human ALOX15B cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (13)
Ask a questionYes, certain ALOX15B gene mutations are closely associated with the onset of several autoimmune diseases.
The expression level of ALOX15B in tumors is closely related to the treatment response and prognosis of patients.
Whether ALOX15B is related to the occurrence of diseases related to the blood circulation system (such as heart disease, thrombosis, etc.) still needs further research.
Mutations in ALOX15B can lead to a variety of diseases, such as asthma and autoimmune diseases.
Yes, ALOX15B may be a target for the treatment of certain skin diseases.
Studies have shown that the level of ALOX15B expression in asthma patients is positively correlated with the severity of the disease.
Yes, ALOX15B can promote an increased systemic inflammatory response in patients with asthma.
Yes, some studies suggest that ALOX15B has the potential to be a new target for tumor therapy.
Yes, ALOX15B is associated with the occurrence, development and metastasis of various cancers.
The enzyme encoded by ALOX15B is mainly involved in the metabolism of arachidonic acid (AA), which is closely related to biological processes such as inflammation and immune regulation.
Many experimental studies have shown that ALOX15B is closely related to the pathogenesis and pathophysiological mechanism of asthma.
ALOX15B can inhibit angiogenesis and thus play a role in tumor growth and metastasis.
Yes, ALOX15B is closely related to the onset and progression of many skin diseases (such as psoriasis, psoriasis, etc.).
Customer Reviews (4)
Write a reviewBy using this recombinant protein, the efficiency of my experiments was significantly improved, and unnecessary waste of time was also reduced.
I appreciate the attention paid to product quality by this recombinant protein manufacturer, and their recombinant proteins are very stable, which makes our experiments smoother.
The catalytic activity of this protein is very powerful and can effectively accelerate the process of chemical reactions, which brings great convenience to our experiments.
The reproducibility of the Western blot was significantly improved using this recombinant protein.
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