Recombinant Human ALPP protein(Ile23-Asp506), His-tagged
Cat.No. : | ALPP-219H |
Product Overview : | Recombinant Human ALPP (AAH09647.1) (Ile23-Asp506) was expressed in Yeast with a polyhistidine tag at the C-terminus. |
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Source : | Yeast |
Species : | Human |
Tag : | C-His |
Protein length : | Ile23-Asp506 |
Form : | Lyophilized from sterile 50 mM Tris-Acetate, 1 mM EDTA, 20 % glycerol, pH 7. 5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Molecular Mass : | The recombinant human ALPP consists of 494 amino acids and predicts a molecular mass of 54.1 KDa. It migrates as an approximately 66 KDa band in SDS-PAGE under reducing conditions. |
Purity : | > 80 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | ALPP alkaline phosphatase, placental [ Homo sapiens ] |
Official Symbol : | ALPP |
Synonyms : | ALPP; alkaline phosphatase, placental; alkaline phosphatase, placental (Regan isozyme); alkaline phosphatase, placental type; Regan isozyme; PLAP-1; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme; ALP; PALP; PLAP; FLJ61142; |
Gene ID : | 250 |
mRNA Refseq : | NM_001632 |
Protein Refseq : | NP_001623 |
MIM : | 171800 |
UniProt ID : | P05187 |
Products Types
◆ Recombinant Protein | ||
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ALPP-124H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
ALPP-125H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
ALPP-302H | Recombinant Human ALPP Protein, His tagged | +Inquiry |
ALPP-2558H | Recombinant Human ALPP protein(31-500 aa), C-His-tagged | +Inquiry |
◆ Native Protein | ||
ALPP-8005H | Native Human Placental Alkaline Phosphatase | +Inquiry |
ALPP-8347H | Native Human ALPP | +Inquiry |
◆ Lysates | ||
ALPP-8893HCL | Recombinant Human ALPP 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionALPP may serve as a diagnostic biomarker for specific diseases, allowing for disease detection and monitoring, and its targeting could hold therapeutic potential in certain pathological conditions.
ALPP participates in the metabolism and turnover of its substrate(s), including the hydrolysis of phosphoester bonds and the regulation of cellular phosphate homeostasis.
ALPP regulates downstream signaling pathways and molecular interactions involved in cellular processes like phosphate metabolism, intracellular signaling, and extracellular matrix remodeling.
ALPP gene expression is regulated by transcription factors, epigenetic modifications, and signaling pathways involved in cellular homeostasis and disease processes.
ALPP is localized to specific cellular compartments, such as the plasma membrane, endoplasmic reticulum, or lysosomes, and its trafficking may be regulated by sorting signals and intracellular transport machinery.
ALPP activity can be modulated by factors such as pH, calcium, and inhibitors, which can affect its catalytic efficiency and cellular functions.
ALPP deficiency or dysregulation is associated with various diseases, including metabolic disorders, bone diseases, and certain cancers, highlighting its pathological implications.
Manipulating ALPP activity and function could offer strategies to modulate cellular processes and disease outcomes, potentially leading to therapeutic interventions and improved patient outcomes.
ALPP expression and activity exhibit dynamic changes during development, cellular differentiation, and disease progression, reflecting its roles in different physiological and pathological contexts.
ALPP shows a tissue-specific expression pattern, with higher levels in tissues such as liver, bone, and kidney, and lower levels in other organs.
Customer Reviews (3)
Write a reviewHigh-throughput screening compatibility.
Consistent protein expression analysis.
Precise protein quantification in ELISA.
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