Description : |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
59.17 kDa |
AA Sequence : |
MRDLPLTSLALVLSALGALLGTEAL RAEEPAVGTSGLIFREDLDWPPGSP QEPLCLVALGGDSNGSSSPLRVVGA LSAYEQAFLGAVQRARWGPRDLATF GVCNTGDRQAALPSLRRLGAWLRDP GGQRLVVLHLEEVTWEPTPSLRFQE PPPGGAGPPELALLVLYPGPGPEVT VTRAGLPGAQSLCPSRDTRYLVLAV DRPAGAWRGSGLALTLQPRGEDSRL STARLQALLFGDDHRCFTRMTPALL LLPRSEPAPLPAHGQLDTVPFPPPR PSAELEESPPSADPFLETLTRLVRA LRVPPARASAPRLALDPDALAGFPQ GLVNLSDPAALERLLDGEEPLLLLL RPTAATTGDPAPLHDPTSAPWATAL ARRVAAELQAAAAELRSLPGLPPAT APLLARLLALCPGGPGGLGDPLRAL LLLKALQGLRVEWRGRDPRGPGRAQ RSAGATAADGPCALRELSVDLRAER SVLIPETYQANNCQGVCGWPQSDRN PRYGNHVVLLLKMQARGAALARPPC CVPTAYAGKLLISLSEERISAHHVP NMVATECGCRTRTRPLEQKLISEED LAANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |