Recombinant Human Androgen Receptor protein

• Cat.No.: AR-001H
• Product Overview: Recombinant Human Androgen Receptor protein was expressed in Insect cell.

Specification

• Description: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: Insect cell
• Species: Human
• Form: PBS buffer, pH 7.4.
• Molecular Mass: ~ 101 kDa
• AA Sequence: HHHHHHMEVQLGLGRVYPRPPSKTY RGAFQNLFQSVREVIQNPGPRHPEA ASAAPPGASLLLLQQQQQQQQQQQQ QQQQQQQQQQQETSPRQQQQQQGED GSPQAHRRGPTGYLVLDEEQQPSQP QSALECHPERGCVPEPGAAVAASKG LPQQLPAPPDEDDSAAPSTLSLLGP TFPGLSSCSADLKDILSEASTMQLL QQQQQEAVSEGSSSGRAREASGAPT SSKDNYLGGTSTISDNAKELCKAVS VSMGLGVEALEHLSPGEQLRGDCMY APLLGVPPAVRPTPCAPLAECKGSL LDDSAGKSTEDTAEYSPFKGGYTKG LEGESLGCSGSAAAGSSGTLELPST LSLYKSGALDEAAAYQSRDYYNFPL ALAGPPPPPPPPHPHARIKLENPLD YGSAWAAAAAQCRYGDLASLHGAGA AGPGSGSPSAAASSSWHTLFTAEEG QLYGPCGGGGGGGGGGGGGGGGGGG GGGGEAGAVAPYGYTRPPQGLAGQE SDFTAPDVWYPGGMVSRVPYPSPTC VKSEMGPWMDSYSGPYGDMRLETAR DHVLPIDYYFPPQKTCLICGDEASG CHYGALTCGSCKVFFKRAAEGKQKY LCASRNDCTIDKFRRKNCPSCRLRK CYEAGMTLGARKLKKLGNLKLQEEG EASSTTSPTEETTQKLTVSHIEGYE CQPIFLNVLEAIEPGVVCAGHDNNQ PDSFAALLSSLNELGERQLVHVVKW AKALPGFRNLHVDDQMAVIQYSWMG LMVFAMGWRSFTNVNSRMLYFAPDL VFNEYRMHKSRMYSQCVRMRHLSQE FGWLQITPQEFLCMKALLLFSIIPV DGLKNQKFFDELRMNYIKELDRIIA CKRKNPTSCSRRFYQLTKLLDSVQP IARELHQFTFDLLIKSHMVSVDFPE MMAEIISVQVPKILSGKVKPIYFHT Q YPYDVPDYA
• Purity: >85 %
• Storage: Long Term Storage at -20 centigrade to -80 centigrade. Avoid freeze/thaw cycles.
• Concentration: 0.15 ug/ul
• Publication:
  (+)-JJ-74–138 is a Novel Noncompetitive Androgen Receptor Antagonist (2022)

Gene Information

• Gene Name: AR androgen receptor [ Homo sapiens (human) ]
• Official Symbol: AR
• Synonyms: KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA
• Gene ID: 367
• mRNA Refseq: NM_000044
• Protein Refseq: NP_000035
• MIM: 313700
• UniProt ID: P21730