Recombinant Human ANXA13, His-tagged

• Cat.No.: ANXA13-3508H
• Product Overview: Recombinant human ANXA13 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Cat. No.: ANXA13-3508H
• Description: Annexin A13, also known as ANXA13, is a member of the annexin protein family. Members of the annexin family play a role in cytoskeletal interactions, phospholipase inhibition, regulation of cellular growth, and intracellular signal transduction pathways. ANXA13 is considered the original progenitor of the 12 members of vertebrate annexins. The expression of ANXA13 is highly tissue-specific, being expressed only in intestinal and kidney epithelial cells. This expression is associated with a highly differentiated intracellular transport function.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 0.1M NaCl, 1mM EDTA
• Molecular Weight: 37.5 kDa (336aa), confirmed by MALDI-TOF
• Purity: > 90% by SDS - PAGE
• Concentration: 0.5 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGNRHAKASS PQGFDVDRDA KKLNKACKGM GTNEAAIIEI LSGRTSDERQ QIKQKYKATY GKELEEVLKSELSGNFEKTA LALLDRPSEY AARQLQKAMK GLGTDESVLI EVLCTRTNKE IIAIKEAYQR LFDRSLESDV KGDTSGNLKK ILVSLLQANR NEGDDVDKDL AGQDAKDLYD AGEGRWGTDE LAFNEVLAKR SYKQLRATFQ AYQILIGKDI EEAIEEETSG DLQKAYLTLV RCAQDCEDYFAERLYKSMKG AGTDEETLIR IVVTRAEVDL QGIKAKFQEK YQKSLSDMVR SDTSGDFRKL LVALLH
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: ANXA13 annexin A13 [ Homo sapiens ]
• Synonyms: annexin A13; ISA; ANX13; MGC150460; ANXA13; annexin-13; annexin XIII; intestine-specific annexin; annexin, intestine-specific; Annexin A13
• Gene ID: 312
• mRNA Refseq: NM_001003954
• Protein Refseq: NP_001003954
• MIM: 602573
• UniProt ID: P27216
• Chromosome Location: 8q24.13
• Function: calcium ion binding; calcium-dependent phospholipid binding

Reviews

03/16/2021

Researchers can rely on the ANXA13 protein's specificity and sensitivity to obtain accurate and reliable results.

01/12/2020

the ANXA13 protein's versatility allows it to be effectively employed in various experimental designs, further enhancing its suitability for diverse research needs.

01/23/2019

The ANXA13 protein comes highly recommended for a variety of applications, particularly in ELISA and protein electron microscopy structure analysis.

11/19/2016

In protein electron microscopy structure analysis, the ANXA13 protein demonstrates outstanding performance.

Q&As

Are there any known mutations in the ANXA13 gene that are associated with disease?

Currently, there are no known mutations in the ANXA13 gene that have been directly linked to any specific diseases. However, genetic variations in the ANXA13 gene may exist and could potentially contribute to disease susceptibility or affect ANXA13 function. Further studies are needed to explore the genetic variability of ANXA13 and its potential implications in various diseases.

What cellular compartments or organelles is ANXA13 localized to?

ANXA13, like other annexin proteins, can be found in various cellular compartments or organelles. Annexin proteins have been detected on the plasma membrane, as well as in the cytoplasm, nucleus, mitochondria, endoplasmic reticulum, and lysosomes. The precise subcellular localization of ANXA13 may depend on the specific cell type and experimental conditions.

Are there any diseases associated with ANXA13 mutations or dysregulation?

Mutations in the ANXA13 gene have been associated with certain diseases, such as amyloidosis. Amyloidosis is a disorder characterized by the abnormal accumulation of proteins in various tissues and organs, leading to organ dysfunction. However, research into the specific role of ANXA13 mutations in the development of amyloidosis is still ongoing.

Are there any diseases associated with ANXA13 mutations or dysregulation?

Mutations in the ANXA13 gene have been associated with certain diseases, such as amyloidosis. Amyloidosis is a disorder characterized by the abnormal accumulation of proteins in various tissues and organs, leading to organ dysfunction. However, research into the specific role of ANXA13 mutations in the development of amyloidosis is still ongoing.

Is ANXA13 involved in cancer?

ANXA13 has been implicated in certain cancers. For example, studies have suggested that ANXA13 may promote gastric cancer progression by influencing tumor cell growth and metastasis. However, the exact mechanisms and extent of ANXA13 involvement in cancer development and progression are not fully understood and require further investigation.

Is ANXA13 involved in any physiological processes?

While the specific physiological processes involving ANXA13 are not well defined, annexins, in general, have been implicated in various cellular functions. Annexin proteins are known to be involved in membrane repair, membrane trafficking, regulation of ion channels, cell signaling, and apoptosis. It is possible that ANXA13 may have similar roles, but further research is needed to determine its specific functions.

In which tissues or organs is ANXA13 expressed?

ANXA13 is known to be expressed in various tissues, including the brain, kidney, liver, lung, and pancreas, among others. Its expression pattern may vary depending on the cell type and developmental stage.